An approach towards construction of amide C–N bonds under mild conditions through rhodium(III) catalysis has been explored. Previous waste-free amidations were generally limited to the condensation of carboxylic acids and amines. In this report, we directly applied amination of the aldehyde C(sp2)–H bond to extend the scope of amidation reactions. The amination shows a wide substrates scope, and several important functional groups were tolerated under the benign reaction conditions. The synthesized amides are important precursors for the preparation of benzoxazinone derivatives, found in various bioactive natural products.q.
|Number of pages||8|
|Journal||European Journal of Organic Chemistry|
|Publication status||Published - 2017 Jul 7|
- Directed C–H amidation
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry