Creatine Phosphokinase-Linked Immunoglobulin Associated with Hypokalemic Myopathy

Jin Hoshino, Tetsuya Nakamura, Noboru Nushiro, Kunio Sato, Tetsuo Sakamaki, Kazuhiko Murata, Hiroyuki Arai, Toshio Fukusato

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We present three women with hypokalemic myopathy in whom serum creatine phosphokinase (CPK) was bound to serum immunoglobulin (macro-CPK). In all three cases, CPK isozyme electrophoresis demonstrated an extra CPK band between CPK-MM and CPK-MB. The bound immunoglobulins were identified as IgA/A-κ and λ, IgA-λ and IgA-κ and λ, respectively. In all cases, histological examination of the biopsied muscles revealed necrotic and/or regenerating fibers. In each patient, potassium replacement therapy returned the macro-CPK as well as the marked elevations of serum muscle enzymes to normal. Taken together with other recent reports, our findings suggested that CPK-immunoglobulin binding may be related to the emergence of pathophysiology of hypokalemic myopathy.

Original languageEnglish
Pages (from-to)1210-1214
Number of pages5
JournalInternal Medicine
Issue number12
Publication statusPublished - 1995
Externally publishedYes


  • macro creatine kinase
  • muscle biopsy
  • potassium replacement

ASJC Scopus subject areas

  • Internal Medicine


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