Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007

K. Mizuta, Y. Aoki, A. Suto, K. Ootani, N. Katsushima, T. Itagaki, A. Ohmi, M. Okamoto, H. Nishimura, Y. Matsuzaki, S. Hongo, K. Sugawara, H. Shimizu, T. Ahiko

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89 Citations (Scopus)


We isolated and identified six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological analysis of 83 residents in Yamagata in 2004 showed that differences in the NT Ab titer of each individual against the different subgenogroups were mostly within 4-fold. Furthermore, sera from guinea pigs, immunized with the B2 and C1 strains indicated cross-antigenicity among the seven different subgenogroups. In conclusion, our results showed that cross-antigenicity exists among EV71 strains from different subgenogroups circulating in the community through genomic evolution. Our results also suggest that eliciting neutralizing antibodies against one genotype is likely to confer cross-neutralization against other genotypes.

Original languageEnglish
Pages (from-to)3153-3158
Number of pages6
Issue number24
Publication statusPublished - 2009 May 21
Externally publishedYes


  • Cross-antigenicity
  • Enterovirus type 71
  • Subgenogroup

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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