TY - JOUR
T1 - Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007
AU - Mizuta, K.
AU - Aoki, Y.
AU - Suto, A.
AU - Ootani, K.
AU - Katsushima, N.
AU - Itagaki, T.
AU - Ohmi, A.
AU - Okamoto, M.
AU - Nishimura, H.
AU - Matsuzaki, Y.
AU - Hongo, S.
AU - Sugawara, K.
AU - Shimizu, H.
AU - Ahiko, T.
N1 - Funding Information:
We thank the medical staff and people of Yamagata Prefecture for their collaboration in specimen collection for the surveillance of viral infectious diseases. We also thank Dr. T. Ito, Laboratory Animal Center, Yamagata University, Faculty of Medicine, and Dr. H. Yoshida, Department of Virology II, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan for their excellent technical assistance. This work was partially supported by Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labour and Welfare, Japan.
PY - 2009/5/21
Y1 - 2009/5/21
N2 - We isolated and identified six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological analysis of 83 residents in Yamagata in 2004 showed that differences in the NT Ab titer of each individual against the different subgenogroups were mostly within 4-fold. Furthermore, sera from guinea pigs, immunized with the B2 and C1 strains indicated cross-antigenicity among the seven different subgenogroups. In conclusion, our results showed that cross-antigenicity exists among EV71 strains from different subgenogroups circulating in the community through genomic evolution. Our results also suggest that eliciting neutralizing antibodies against one genotype is likely to confer cross-neutralization against other genotypes.
AB - We isolated and identified six subgenogroups (B2, B4, B5, C1, C2, and C4) of enterovirus 71 (EV71) between 1990 and 2007 in Yamagata, Japan. We measured neutralizing antibody (NT Ab) titers against those subgenogroup strains and the BrCr reference strain for antigenic analysis. Serological analysis of 83 residents in Yamagata in 2004 showed that differences in the NT Ab titer of each individual against the different subgenogroups were mostly within 4-fold. Furthermore, sera from guinea pigs, immunized with the B2 and C1 strains indicated cross-antigenicity among the seven different subgenogroups. In conclusion, our results showed that cross-antigenicity exists among EV71 strains from different subgenogroups circulating in the community through genomic evolution. Our results also suggest that eliciting neutralizing antibodies against one genotype is likely to confer cross-neutralization against other genotypes.
KW - Cross-antigenicity
KW - Enterovirus type 71
KW - Subgenogroup
UR - http://www.scopus.com/inward/record.url?scp=67349090037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349090037&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2009.03.060
DO - 10.1016/j.vaccine.2009.03.060
M3 - Article
C2 - 19446185
AN - SCOPUS:67349090037
SN - 0264-410X
VL - 27
SP - 3153
EP - 3158
JO - Vaccine
JF - Vaccine
IS - 24
ER -
