@article{e68c5220b63948d7ba86684fc188ff2a,
title = "Cross-Regulation of an Artificial Metalloenzyme",
abstract = "Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.",
keywords = "artificial metalloenzymes, biocatalysis, cross-regulation, hydrogenation, urease",
author = "Yasunori Okamoto and Ward, {Thomas R.}",
note = "Funding Information: Generous support from the Swiss National Science Foundation (grant 200020_162348) and from the NCCR Molecular Systems Engineering, an advanced ERC grant (DrEAM agreement number 694424) as well as a JSPS Overseas research fellowship to Y.O. is gratefully acknowledged. We thank Dr. M. D{\"u}rrenberger, Dr. V. K{\"o}hler and Dr. J. Rebelein for enlightening discussions and Umicore for a loan of [Cp*IrCl2]2. Publisher Copyright: {\textcopyright} 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",
year = "2017",
month = aug,
day = "14",
doi = "10.1002/anie.201702181",
language = "English",
volume = "56",
pages = "10156--10160",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "34",
}