Cross-Regulation of an Artificial Metalloenzyme

Yasunori Okamoto, Thomas R. Ward

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Cross-regulation of complex biochemical reaction networks is an essential feature of living systems. In a biomimetic spirit, we report on our efforts to program the temporal activation of an artificial metalloenzyme via cross-regulation by a natural enzyme. In the presence of urea, urease slowly releases ammonia that reversibly inhibits an artificial transfer hydrogenase. Addition of an acid, which acts as fuel, allows to maintain the system out of equilibrium.

Original languageEnglish
Pages (from-to)10156-10160
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number34
Publication statusPublished - 2017 Aug 14


  • artificial metalloenzymes
  • biocatalysis
  • cross-regulation
  • hydrogenation
  • urease


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