We report measurements of cross sections and analyzing powers for nucleon-knockout (pnp) reactions of H2, Li6, and C12 at 296 MeV using the RCNP NPOL3 neutron detector and large acceptance spectrometer. The 1s and 1p knockout reactions were successfully separated with a separation-energy resolution of approximately 6 MeV. The resulting data were compared with plane-wave and distorted-wave impulse approximation calculations employing the nucleon-nucleon t matrix in free space. No significant differences were identified in the case of the present analyzing power data, in contrast to the significant reductions observed in (p2p) values. The conventional Pauli blocking and nuclear binding effects with the g matrix and the relativistic effect of nucleon mass reduction in the nuclei are also discussed.