TY - JOUR
T1 - Crossloads of metabolism and CKD
AU - Suzuki, Takehiro
AU - Abe, Takaaki
N1 - Publisher Copyright:
© 2018 International Society of Nephrology
PY - 2018/8
Y1 - 2018/8
N2 - Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein. Their finding develops a new aspect for diagnosing and predicting the prognosis of CKD.
AB - Sensitive and useful biomarkers for predicting chronic kidney disease (CKD) and its prognosis are urgently needed. Using a nontargeted metabolomic approach, Hu et al. explored an established CKD cohort, Modification of Diet in Renal Disease, as well as a validation cohort, African American Study of Kidney Disease and Hypertension. They identified 3 serum metabolites (ribonate, fumarate, and allantoin) significantly associated with mortality in CKD even after statistical adjustment by multiple clinical covariates including glomerular filtration rate and urinary protein. Their finding develops a new aspect for diagnosing and predicting the prognosis of CKD.
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U2 - 10.1016/j.kint.2018.03.023
DO - 10.1016/j.kint.2018.03.023
M3 - Comment/debate
C2 - 30031444
AN - SCOPUS:85049623719
SN - 0085-2538
VL - 94
SP - 242
EP - 243
JO - Kidney International
JF - Kidney International
IS - 2
ER -