Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

Taku Fujimura; Yumi Kambayashi; Setsuya Aiba

doi:10.4161/onci.21176

Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

Taku Fujimura, Yumi Kambayashi, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Comment/debate

82 Citations (Scopus)

Abstract

Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.

Original language	English
Pages (from-to)	1433-1434
Number of pages	2
Journal	OncoImmunology
Volume	1
Issue number	8
DOIs	https://doi.org/10.4161/onci.21176
Publication status	Published - 2012

Keywords

B7-H1
IL-10
MDSC
Melanoma
Tregs

Access to Document

10.4161/onci.21176

Cite this

@article{cd1fc971222c4fc98168ec1c5bb26b09,

title = "Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth",

abstract = "Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.",

keywords = "B7-H1, IL-10, MDSC, Melanoma, Tregs",

author = "Taku Fujimura and Yumi Kambayashi and Setsuya Aiba",

year = "2012",

doi = "10.4161/onci.21176",

language = "English",

volume = "1",

pages = "1433--1434",

journal = "OncoImmunology",

issn = "2162-4011",

publisher = "Landes Bioscience",

number = "8",

}

TY - JOUR

T1 - Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

AU - Fujimura, Taku

AU - Kambayashi, Yumi

AU - Aiba, Setsuya

PY - 2012

Y1 - 2012

N2 - Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.

AB - Myeloid derived suppressor cells (MDSCa) are a heterogeneous population of cells that promote an immunosuppressive environment in tumor-bearing hosts. Recently, B7-H1 signaling has been reported to be critical for the maintainancer of regulatory T cells (Tregs), another immunosuppressive cell population. Here, we discuss the immunosuppressive function of B7-H1 on MDSCs, and the functional crosstalk between Tregs and MDSCs.

KW - B7-H1

KW - IL-10

KW - MDSC

KW - Melanoma

KW - Tregs

UR - http://www.scopus.com/inward/record.url?scp=84885745449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885745449&partnerID=8YFLogxK

U2 - 10.4161/onci.21176

DO - 10.4161/onci.21176

M3 - Comment/debate

AN - SCOPUS:84885745449

SN - 2162-4011

VL - 1

SP - 1433

EP - 1434

JO - OncoImmunology

JF - OncoImmunology

IS - 8

ER -

Crosstalk between regulatory T cells (Tregs) and myeloid derived suppressor cells (MDSCs) during melanoma growth

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this