Crystallization of all trans-β-carotene by supercritical carbon dioxide antisolvent via co-axial nozzle

Tomohiko Kodama, Masaki Honda, Siti Machmudah, Wahyudiono, Hideki Kanda, Motonobu Goto

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The crystallization of β-carotene through supercritical antisolvent process with carbon dioxide (CO2) as an antisolvent has been demonstrated. The experiments were conducted at temperatures of 40 - 60o C and pressures of 10 - 14 MPa at a constant CO2 flow rate. As a starting material, β-carotene powder was dissolved in dichloromethane (DCM). Results of UV-vis spectrophotometry and GC-MS analysis showed that there was no remaining DCM solvent in the β-carotene particles products. It showed that CO2 has successfully removed DCM from β-carotene particles products. The product characterization by using fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) showed that the CO2 solvent did not impregnate to the β-carotene particles products. Results from scanning electron microscope (SEM) images showed that the β-carotene particles products were successfully prepared in plate-like shape morphologies with size around 1 μm.

Original languageEnglish
Pages (from-to)25-38
Number of pages14
JournalEngineering Journal
Issue number3
Publication statusPublished - 2018 Jun 28
Externally publishedYes


  • Crystallization
  • DCM
  • SCCO
  • Supercritical antisolvent
  • β-Carotene

ASJC Scopus subject areas

  • Engineering(all)


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