TY - JOUR
T1 - CSF-chemokines in HTLV-I-associated myelopathy
T2 - CXCL10 up-regulation and therapeutic effect of interferon-α
AU - Narikawa, Koichi
AU - Fujihara, Kazuo
AU - Misu, Tatsuro
AU - Feng, Juan
AU - Fujimori, Juichi
AU - Nakashima, Ichiro
AU - Miyazawa, Isabelle
AU - Saito, Hiroshi
AU - Sato, Shigeru
AU - Itoyama, Yasuto
N1 - Funding Information:
The authors thank Dr. Tatsufumi Nakamura (Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki, Japan) for helpful suggestions and Mr. Brent Bell for reading the manuscript. This work was supported by the grants-in-aid for General Scientific Research of the Ministry of Education, Culture, Sports, Science and Technology of Japan and the Tawara's Endowment for HAM Research.
PY - 2005/2
Y1 - 2005/2
N2 - We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-α therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.
AB - We measured four chemokines in the cerebrospinal fluid (CSF) in human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with ELISA. CXCL10/IP-10, a T cell type 1 (Th1)-associated chemokine, was significantly elevated in HAM/TSP compared with controls, and the values were even significantly higher in HAM/TSP than in multiple sclerosis (MS) in which CXCL10/IP-10 up-regulation was previously reported. Among Th2-associated chemokines, CCL17/TARC and CCL11/Eotaxin in HAM/TSP were not different from those in controls. As shown in MS, CCL2/MCP-1 was significantly lower in HAM/TSP than in control. Following interferon (IFN)-α therapy in HAM/TSP, CCL2/MCP-1 became significantly higher than that before therapy, which may reflect a Th2 induction, while CXCL10/IP-10 remained elevated.
KW - Chemokine
KW - Human T-lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis
KW - Multiple sclerosis
KW - Th1
KW - Th2
UR - http://www.scopus.com/inward/record.url?scp=19944431445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19944431445&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2004.10.011
DO - 10.1016/j.jneuroim.2004.10.011
M3 - Article
C2 - 15652417
AN - SCOPUS:19944431445
SN - 0165-5728
VL - 159
SP - 177
EP - 182
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -