CTA-Based Non-invasive Estimation of Pressure Gradients Across a CoA: a Validation Against Cardiac Catheterisation

Mingzi Zhang, Jinlong Liu, Haibo Zhang, David I. Verrelli, Qian Wang, Liwei Hu, Yujie Li, Makoto Ohta, Jinfen Liu, Xi Zhao

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Non-invasive estimation of pressure gradients across a coarctation of the aorta (CoA) can reduce the need for diagnostic cardiac catheterisation. We aimed to validate two novel computational strategies—target-value approaching (TVA) and target-value fixing (TVF)—together with unrefined Doppler estimates, and to compare their diagnostic performance in identifying critical pressure drops for 40 patients. Compared to catheterisation, no statistically significant difference was demonstrated with TVA (P = 0.086), in contrast to TVF (P = 0.005) and unrefined Doppler echocardiography (P < 0.001). TVA manifested the strongest correlation with catheterisation (r = 0.93), compared to TVF (r = 0.83) and echocardiography (r = 0.67) (all P < 0.001). In discriminating pressure gradients greater than 20 mmHg, TVA, TVF, and echocardiography had respective sensitivities of 0.92, 0.88, and 0.80; specificities of 0.93, 0.80, and 0.73; and AUCs of 0.96, 0.89, and 0.80. The TVA strategy may serve as an effective and easily implemented approach to be used in clinical management of patients with CoA. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)873-882
Number of pages10
JournalJournal of Cardiovascular Translational Research
Issue number5
Publication statusPublished - 2021 Oct


  • Cardiac catheterisation
  • Coarctation of the aorta
  • Computational fluid dynamics
  • CTA
  • Non-invasive estimation
  • Pressure gradient


Dive into the research topics of 'CTA-Based Non-invasive Estimation of Pressure Gradients Across a CoA: a Validation Against Cardiac Catheterisation'. Together they form a unique fingerprint.

Cite this