TY - JOUR
T1 - Cutting edge
T2 - The common γ-chain is an indispensable subunit of the IL-21 receptor complex
AU - Asao, H.
AU - Okuyama, C.
AU - Kumaki, S.
AU - Ishii, N.
AU - Tsuchiya, S.
AU - Foster, D.
AU - Sugamura, K.
PY - 2001/7/1
Y1 - 2001/7/1
N2 - The common γ-chain (γc) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the γc is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on γc-deficient ED40515- cells, IL-21 is unable to transduce any intracytoplasmic signals. However, in EDγ-16 cells, a γc-transfected ED40515- cell line, IL-21 binds to the IL-21R and can activate Janus kinase (JAK)1, JAK3, STAT1, and STAT3. The chemical cross-linking study reveals the direct binding of IL-21 to the γc. These data clearly demonstrate that the γc is an indispensable subunit of the functional IL-21R complex.
AB - The common γ-chain (γc) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the γc is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on γc-deficient ED40515- cells, IL-21 is unable to transduce any intracytoplasmic signals. However, in EDγ-16 cells, a γc-transfected ED40515- cell line, IL-21 binds to the IL-21R and can activate Janus kinase (JAK)1, JAK3, STAT1, and STAT3. The chemical cross-linking study reveals the direct binding of IL-21 to the γc. These data clearly demonstrate that the γc is an indispensable subunit of the functional IL-21R complex.
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U2 - 10.4049/jimmunol.167.1.1
DO - 10.4049/jimmunol.167.1.1
M3 - Article
C2 - 11418623
AN - SCOPUS:0035400054
SN - 0022-1767
VL - 167
SP - 1
EP - 5
JO - Journal of Immunology
JF - Journal of Immunology
IS - 1
ER -