Cycloamylose-based biomaterial: Nanogel of Cholesterol-bearing cationic cycloamylose for siRNA delivery

Sayaka Toita; Yuki Soma; Nobuyuki Morimoto; Kazunari Akiyoshi

doi:10.1246/cl.2009.1114

Cycloamylose-based biomaterial: Nanogel of Cholesterol-bearing cationic cycloamylose for siRNA delivery

Sayaka Toita, Yuki Soma, Nobuyuki Morimoto, Kazunari Akiyoshi

ENG - Materials Processing

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20-40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.

Original language	English
Pages (from-to)	1114-1115
Number of pages	2
Journal	Chemistry Letters
Volume	38
Issue number	11
DOIs	https://doi.org/10.1246/cl.2009.1114
Publication status	Published - 2009

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1246/cl.2009.1114

Cite this

@article{ece4f163a84d456f86dc01c3340871e6,

title = "Cycloamylose-based biomaterial: Nanogel of Cholesterol-bearing cationic cycloamylose for siRNA delivery",

abstract = "A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20-40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.",

author = "Sayaka Toita and Yuki Soma and Nobuyuki Morimoto and Kazunari Akiyoshi",

year = "2009",

doi = "10.1246/cl.2009.1114",

language = "English",

volume = "38",

pages = "1114--1115",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "Chemical Society of Japan",

number = "11",

}

TY - JOUR

T1 - Cycloamylose-based biomaterial

T2 - Nanogel of Cholesterol-bearing cationic cycloamylose for siRNA delivery

AU - Toita, Sayaka

AU - Soma, Yuki

AU - Morimoto, Nobuyuki

AU - Akiyoshi, Kazunari

PY - 2009

Y1 - 2009

N2 - A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20-40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.

AB - A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20-40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.

UR - http://www.scopus.com/inward/record.url?scp=75249090947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75249090947&partnerID=8YFLogxK

U2 - 10.1246/cl.2009.1114

DO - 10.1246/cl.2009.1114

M3 - Article

AN - SCOPUS:75249090947

SN - 0366-7022

VL - 38

SP - 1114

EP - 1115

JO - Chemistry Letters

JF - Chemistry Letters

IS - 11

ER -

Cycloamylose-based biomaterial: Nanogel of Cholesterol-bearing cationic cycloamylose for siRNA delivery

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this