CYP2A13 genetic polymorphisms in relation to the risk of bladder cancer in Japanese smokers

Masaki Kumondai, Hiroki Hosono, Kazuhiko Orikasa, Yoichi Arai, Tomio Arai, Haruhiko Sugimura, Seiichiro Ozono, Takayuki Sugiyama, Tatsuya Takayama, Takamitsu Sasaki, Noriyasu Hirasawa, Masahiro Hiratsuka

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Tobacco-specific nitrosamines including 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N-nitrosonornicotine (NNN), which can be activated by the metabolic enzyme CYP2A13, are potent procarcinogens. Smoking plays a role in carcinogenesis in the human bladder, which expresses CYP2A13 at a relatively high level. Numerous genetic polymorphisms of CYP2A13 causing amino acid substitution might reduce CYP2A13 metabolic activity toward NNK and NNN, resulting in decreased susceptibility to bladder cancer. The aim of this study was to reveal any association between bladder cancer development and CYP2A13 genetic polymorphisms in Japanese smokers. The CYP2A13 genotype of each subject (163 bladder cancer patients and 161 controls) was determined by next-generation sequencing (NGS) of the full CYP2A13 gene. All samples were genotyped for five CYP2A13 variant alleles (CYP2A13∗2, ∗3, ∗4, ∗6, ∗7). Based on biological logistic regression, the odds ratio (95% confidence interval) for the CYP2A13∗1/∗2 genotype was 0.34 (0.17-0.69). Thus, CYP2A13 genetic polymorphisms might play important roles in the development of bladder cancer in Japanese smokers.

Original languageEnglish
Pages (from-to)1683-1686
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Issue number10
Publication statusPublished - 2016


  • Bladder cancer
  • CYP2A13
  • Genetic polymorphism
  • Japanese
  • Smoking


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