1,5-Dimethylcytosine (Hdmcyt), which is a model of the naturally occurring 5-methylcytidine nucleobase, has been demonstrated to be capable of binding three metal ions simultaneously, via N(3), monodeprotonated N(4) and O(2). The compound trans-[(NH2Me)2Pt(dmcyt)2Ag 2][NO3]2 1 was prepared from trans-[Pt(NH2Me)2(Hdmyct-N3) 2][NO3]2 and AgNO3 at alkaline pH, and its crystal structure determined. The Pt ⋯ Ag distances within the trinuclear cation are 2.892(1) and 3.040(1) Å. The compound is compared with related mixed Pt-Ag nucleobase complexes as well as other trinuclear d10-d8-d10 systems. Despite the problem of differentiation of the nucleobase arrangement (head-to-head or head-to-tail) due to the pseudo-two-fold symmetry of the 1,5-dimethylcytosine ligand, the head-to-head orientation has unambiguously been established by use of 1H NMR spectroscopy following precipitation of AgCl.
|Number of pages||5|
|Journal||Journal of the Chemical Society. Dalton Transactions|
|Publication status||Published - 1995|