TY - JOUR
T1 - Cytotoxicity of Pure Nanodrugs of SN-38 and Podophyllotoxin Dimers in Human Cancer HepG2, KPL-4, and MCF-7 Cells
AU - Koseki, Yoshitaka
AU - Ikuta, Yoshikazu
AU - Murakami, Tatsuya
AU - Onodera, Tsunenobu
AU - Oikawa, Hidetoshi
AU - Cong, Liman
AU - Tada, Hiroshi
AU - Gonda, Kohsuke
AU - Ohuchi, Noriaki
AU - Kasai, Hitoshi
N1 - Funding Information:
This study was supported by The Asahi Glass Foundation and the JST program of Adaptable and Seamless Technology Transfer Program through Target-driven R&D and Grant-in-Aid for Scientific Research (A) (No. 25248044).
Publisher Copyright:
Copyright © Taylor & Francis Group, LLC.
PY - 2015/11/22
Y1 - 2015/11/22
N2 - Pure nanodrugs (PNDs) is a newly designed drug materials, which is a carrier-free drug nanoparticles fabricated by the reprecipitation method. In the present study, the cytotoxicity of PNDs consisting of SN-38 dimer and podophyllotoxin dimer with size in the range 30-50 nm was evaluated in human cancer HepG2, KPL-4, and MCF-7 cells. It was observed that the cytotoxicities of PNDs were changed depending on the type of cells. In addition, PNDs coated with polysorbate 80 showed higher activity than free PNDs, which suggests that the surface state of PNDs was the one of the important factors to affect cytotoxicity.
AB - Pure nanodrugs (PNDs) is a newly designed drug materials, which is a carrier-free drug nanoparticles fabricated by the reprecipitation method. In the present study, the cytotoxicity of PNDs consisting of SN-38 dimer and podophyllotoxin dimer with size in the range 30-50 nm was evaluated in human cancer HepG2, KPL-4, and MCF-7 cells. It was observed that the cytotoxicities of PNDs were changed depending on the type of cells. In addition, PNDs coated with polysorbate 80 showed higher activity than free PNDs, which suggests that the surface state of PNDs was the one of the important factors to affect cytotoxicity.
KW - Cytotoxicity
KW - Podophyllotoxin (PPT)
KW - Pure nanodrugs (PNDs)
KW - Reprecipitation method
KW - SN-38
UR - http://www.scopus.com/inward/record.url?scp=84950247389&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84950247389&partnerID=8YFLogxK
U2 - 10.1080/15421406.2015.1096483
DO - 10.1080/15421406.2015.1096483
M3 - Article
AN - SCOPUS:84950247389
SN - 1542-1406
VL - 622
SP - 1
EP - 5
JO - Molecular Crystals and Liquid Crystals
JF - Molecular Crystals and Liquid Crystals
IS - 1
ER -
