Daily serial hemodynamic data during pregnancy and seasonal variation: The BOSHI study

Hirohito Metoki, Takayoshi Ohkubo, Taku Obara, Konomi Akutsu, Mami Yamamoto, Mami Ishikuro, Kasumi Sakurai, Noriyuki Iwama, Mikiko Katagiri, Junichi Sugawara, Takuo Hirose, Michihiro Sato, Masahiro Kikuya, Katsuyo Yagihashi, Yoichi Matsubara, Nobuo Yaegashi, Shigeru Mori, Masakuni Suzuki, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Although there are some reports that low plasma volume or increased cardiac output is associated with developing preeclampsia, there are few reports of daily serial hemodynamic data during pregnancy. A total of 37 092 home blood pressure (BP) and heart rate (HR) measurements were obtained from 425 normal pregnant women. Heart rate and shock index (SI) gradually increased by gestational week 32 and then decreased, whereas double product (DP) increased linearly during pregnancy. Although systolic BP and DP were consistently and negatively correlated with daily minimum outside temperature, HR and SI were positively correlated with minimum outside temperature in summer.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalClinical and Experimental Hypertension
Issue number4
Publication statusPublished - 2012 Jul


  • blood pressure measurement/monitoring
  • clinical science
  • preeclampsia/ pregnancy
  • self-monitoring of blood pressure


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