TY - JOUR
T1 - dbTMM
T2 - an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
AU - the Tohoku Medical Megabank Project Study Group
AU - Ogishima, Soichi
AU - Nagaie, Satoshi
AU - Mizuno, Satoshi
AU - Ishiwata, Ryosuke
AU - Nakamura, Naoki
AU - Nagase, Sachiko
AU - Nakaya, Naoki
AU - Onuma, Tomomi
AU - Ishikuro, Mami
AU - Obara, Taku
AU - Mugikura, Shunji
AU - Uruno, Akira
AU - Narita, Akira
AU - Makino, Satoshi
AU - Tamiya, Gen
AU - Shimizu, Ritsuko
AU - Motoike, Ikuko N.
AU - Koshiba, Seizo
AU - Kumada, Kazuki
AU - Hozawa, Atsushi
AU - Kuriyama, Shinichi
AU - Yamamoto, Masayuki
AU - Abe, Michiaki
AU - Aoki, Yuichi
AU - Chida, Koichi
AU - Egawa, Shinichi
AU - Funayama, Takamitsu
AU - Fuse, Nobuo
AU - Hamanaka, Yohei
AU - Hirano, Sachiko
AU - Hiratsuka, Masahiro
AU - Igarashi, Kazuhiko
AU - Ishida, Noriko
AU - Ishii, Naoto
AU - Ishii, Tadashi
AU - Katsuoka, Fumiki
AU - Kawashima, Junko
AU - Kinoshita, Kengo
AU - Kobayashi, Tomoko
AU - Kodama, Eiichi
AU - Kogure, Mana
AU - Kojima, Kaname
AU - Kudo, Hisaaki
AU - Matsubara, Hiroko
AU - Motohashi, Hozumi
AU - Nagami, Fuji
AU - Nakayama, Keiko
AU - Nishijima, Ichiko
AU - Nobukuni, Takahiro
AU - Nochioka, Kotaro
AU - Osumi, Noriko
AU - Otsuki, Akihito
AU - Saito, Sakae
AU - Sakurai-Yageta, Mika
AU - Shirota, Matsuyuki
AU - Tadaka, Shu
AU - Taira, Makiko
AU - Taki, Yasuyuki
AU - Tomita, Hiroaki
AU - Yamaguchi-Kabata, Yumi
AU - Tominaga, Teiji
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
AB - To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called “dbTMM” that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
UR - http://www.scopus.com/inward/record.url?scp=85120991177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85120991177&partnerID=8YFLogxK
U2 - 10.1038/s41439-021-00175-5
DO - 10.1038/s41439-021-00175-5
M3 - Article
AN - SCOPUS:85120991177
SN - 2054-345X
VL - 8
JO - Human Genome Variation
JF - Human Genome Variation
IS - 1
M1 - 44
ER -