De novo Crohn’s disease following orthotopic liver transplantation: A case report and literature review

Takeo Naito; Hisashi Shiga; Katsuya Endo; Masatake Kuroha; Yoichi Kakuta; Yoshitaka Kinouchi; Tooru Shimosegawa

doi:10.2169/internalmedicine.54.3156

De novo Crohn’s disease following orthotopic liver transplantation: A case report and literature review

Takeo Naito, Hisashi Shiga, Katsuya Endo, Masatake Kuroha, Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa

Tohoku University

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The development of de novo Crohn’s disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.

Original language	English
Pages (from-to)	199-204
Number of pages	6
Journal	Internal Medicine
Volume	54
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.54.3156
Publication status	Published - 2015 Jan 15

Keywords

Crohn’s disease
De novo Crohn’s disease
Immunosuppressive Agents
Orthotopic liver transplantation

Access to Document

10.2169/internalmedicine.54.3156

Cite this

@article{f28039d330974c419fcd75ae1c2e316e,

title = "De novo Crohn{\textquoteright}s disease following orthotopic liver transplantation: A case report and literature review",

abstract = "The development of de novo Crohn{\textquoteright}s disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.",

keywords = "Crohn{\textquoteright}s disease, De novo Crohn{\textquoteright}s disease, Immunosuppressive Agents, Orthotopic liver transplantation",

author = "Takeo Naito and Hisashi Shiga and Katsuya Endo and Masatake Kuroha and Yoichi Kakuta and Yoshitaka Kinouchi and Tooru Shimosegawa",

year = "2015",

month = jan,

day = "15",

doi = "10.2169/internalmedicine.54.3156",

language = "English",

volume = "54",

pages = "199--204",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "2",

}

TY - JOUR

T1 - De novo Crohn’s disease following orthotopic liver transplantation

T2 - A case report and literature review

AU - Naito, Takeo

AU - Shiga, Hisashi

AU - Endo, Katsuya

AU - Kuroha, Masatake

AU - Kakuta, Yoichi

AU - Kinouchi, Yoshitaka

AU - Shimosegawa, Tooru

PY - 2015/1/15

Y1 - 2015/1/15

N2 - The development of de novo Crohn’s disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.

AB - The development of de novo Crohn’s disease (CD) after orthotopic liver transplantation (OLT) is rare, possibly due to the continuous use of immunosuppressive treatment. Although several cases of CD following OLT have been reported worldwide, there are currently so such cases in Japan. We herein report the case of a patient who newly developed CD after undergoing OLT for congenital biliary atresia. The patient subsequently underwent ileocecal resection and has since maintained clinical remission. This is the first report of this condition in Japan. We also review the literature concerning cases of de novo inflammatory bowel disease (IBD) developing after OLT, and discuss the causes of and role of immunosuppressive agents in treating IBD.

KW - Crohn’s disease

KW - De novo Crohn’s disease

KW - Immunosuppressive Agents

KW - Orthotopic liver transplantation

UR - http://www.scopus.com/inward/record.url?scp=84921286804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921286804&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.54.3156

DO - 10.2169/internalmedicine.54.3156

M3 - Article

C2 - 25743012

AN - SCOPUS:84921286804

SN - 0918-2918

VL - 54

SP - 199

EP - 204

JO - Internal Medicine

JF - Internal Medicine

IS - 2

ER -

De novo Crohn’s disease following orthotopic liver transplantation: A case report and literature review

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this