TY - JOUR
T1 - Decrease of Plasma Soluble (Pro)renin Receptor by Bariatric Surgery in Patients with Obstructive Sleep Apnea and Morbid Obesity
AU - Nishijima, Tsuguo
AU - Ohba, Koji
AU - Baba, Shigeaki
AU - Kizawa, Testuya
AU - Hosokawa, Keisuke
AU - Endo, Fumiyo
AU - Yamashiro, Yoshihiro
AU - Suwabe, Akira
AU - Sasaki, Akira
AU - Takahashi, Kazuhiro
AU - Sakurai, Shigeru
N1 - Funding Information:
We would like to thank Setsuko Toyomaki, RMT, PSGT (a medical technologist), and Mitsuho Sato (a medical assistant) (both in Department of Laboratory Medicine, Iwate Medical University School of Medicine) for assisting the subjects in wearing PSG. This study was partly supported by a grant from the Blood Pressure and Hormone Science Association (2017) (to K.T.).
Publisher Copyright:
© 2018, Mary Ann Liebert, Inc.
PY - 2018/5
Y1 - 2018/5
N2 - Background: Plasma concentrations of soluble (pro)renin receptor [s(P)RR], which are elevated in patients with obstructive sleep apnea (OSA), have not been studied in morbid obesity. The aim of this study is to clarify effects of bariatric surgery on plasma s(P)RR concentrations and identify associated factors for their changes in OSA patients with morbid obesity. Methods: Twenty-three patients with OSA complicated by morbid obesity (10 men and 13 women; body mass index, 40.7 ± 6.16 kg/m 2 ) without chronic kidney disease were followed up after bariatric surgery. Overnight polysomnography (PSG) was performed before surgery, and 4 and 24 weeks after surgery. Plasma s(P)RR concentrations were measured each morning after PSG. Results: Preoperative plasma s(P)RR concentrations showed significant positive correlations with serum creatinine (P < 0.05), arousal index (P < 0.01), apnea-hypopnea index (AHI) (P < 0.05), apnea index (P < 0.005), and desaturation index (P < 0.05), and a significant inverse correlation with an estimated glomerular filtration rate (P < 0.05). With the improvement of these PSG parameters, plasma s(P)RR concentrations significantly decreased from 15.3 ± 3.6 to 12.5 ± 2.7 ng/mL 4 weeks after surgery, which further decreased to 11.4 ± 2.4 ng/mL 24 weeks after surgery. The association observed before surgery between plasma s(P)RR concentrations and the PSG parameters was not seen after surgery. Conclusions: Bariatric surgery in patients with OSA complicated by morbid obesity decreased plasma s(P)RR concentrations. The most associated factors for their changes were arousal index, AHI, apnea index, and desaturation index.
AB - Background: Plasma concentrations of soluble (pro)renin receptor [s(P)RR], which are elevated in patients with obstructive sleep apnea (OSA), have not been studied in morbid obesity. The aim of this study is to clarify effects of bariatric surgery on plasma s(P)RR concentrations and identify associated factors for their changes in OSA patients with morbid obesity. Methods: Twenty-three patients with OSA complicated by morbid obesity (10 men and 13 women; body mass index, 40.7 ± 6.16 kg/m 2 ) without chronic kidney disease were followed up after bariatric surgery. Overnight polysomnography (PSG) was performed before surgery, and 4 and 24 weeks after surgery. Plasma s(P)RR concentrations were measured each morning after PSG. Results: Preoperative plasma s(P)RR concentrations showed significant positive correlations with serum creatinine (P < 0.05), arousal index (P < 0.01), apnea-hypopnea index (AHI) (P < 0.05), apnea index (P < 0.005), and desaturation index (P < 0.05), and a significant inverse correlation with an estimated glomerular filtration rate (P < 0.05). With the improvement of these PSG parameters, plasma s(P)RR concentrations significantly decreased from 15.3 ± 3.6 to 12.5 ± 2.7 ng/mL 4 weeks after surgery, which further decreased to 11.4 ± 2.4 ng/mL 24 weeks after surgery. The association observed before surgery between plasma s(P)RR concentrations and the PSG parameters was not seen after surgery. Conclusions: Bariatric surgery in patients with OSA complicated by morbid obesity decreased plasma s(P)RR concentrations. The most associated factors for their changes were arousal index, AHI, apnea index, and desaturation index.
KW - apnea-hypopnea index
KW - laparoscopic sleeve gastrectomy
KW - obstructive sleep apnea
KW - Soluble (pro)renin receptor
KW - weight loss
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U2 - 10.1089/met.2017.0153
DO - 10.1089/met.2017.0153
M3 - Article
C2 - 29649379
AN - SCOPUS:85046376461
SN - 1540-4196
VL - 16
SP - 174
EP - 182
JO - Metabolic Syndrome and Related Disorders
JF - Metabolic Syndrome and Related Disorders
IS - 4
ER -
