Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET

Satoshi Yamaguchi, Kenichi Meguro, Masatoshi Itoh, Chika Hayasaka, Masumi Shimada, Hideki Yamazaki, Atsushi Yamadori

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Objective - To investigate the relation between atrophy of the hippocampus and parahippocampal gyrus (the % hippocampal area) and cerebral metabolic rate for glucose (CMRG1c) in Alzheimer's disease. Methods - 13 patients with probable Alzheimer's disease by NINCDS-ADRDA criteria (six men; seven women, mean age 71 years, mini mental state 13.8 (SD 4.6)) and age matched controls were studied. T1 weighted MRI (0.5T) images were used for evaluation of the hippocampal area. With a digitiser system, a percentage of the hippocampal area to the brain (the % hippocampal area) was calculated. Eight patients received another T1 weighted MRI (1.5T) for further evaluation of the minimum thickness of the hippocampus. Regional CMRG1c (rCMRG1c) was measured using PET and the FDG technique. Results - The hippocampal area in patients with Alzheimer's disease was significantly lower than that of controls (P < 0.01). All the cortical rCMRG1c values in patients with Alzheimer's disease were lower than those of controls (P < 0.01). A significant correlation (P < 0.05) was found between the % hippocampal area and rCMRG1c in the temporal lobe, temporoparieto-occipital region, and frontal lobe in Alzhieimer's disease. There was a significant correlation between minimal hippocampal thickness and ipsilateral TPO metabolism on both sides. Conclusion - The ipsilateral correlation between hippocampal decreased TPO metabolism in Alzheimer's disease suggests a functional relation and the asymmetries show that Alzheimer's disease is an asymmetric disease in its early stages.

Original languageEnglish
Pages (from-to)596-600
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number6
Publication statusPublished - 1997 Jun


  • Alzheimer's disease
  • Cerebral metabolic rate for glucose
  • Hippocampus


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