Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients

T. Nagata; H. Onodera; M. Ohuchi; Y. Suzuki; H. Tago; Kazuo Fujihara; N. Ishii; K. Sugamura; Y. Shoji; M. Handa; K. Tabayashi; Y. Itoyama

doi:10.1016/S0165-5728(01)00252-1

Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients

T. Nagata, H. Onodera, M. Ohuchi, Y. Suzuki, H. Tago, Kazuo Fujihara, N. Ishii, K. Sugamura, Y. Shoji, M. Handa, K. Tabayashi, Y. Itoyama

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The thymus is a critical organ for the elimination of autoreactive T cells by apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c-myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c-myc and max, were markedly reduced in MG thymuses. These results indicate that c-myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed.

Original language	English
Pages (from-to)	199-202
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	115
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(01)00252-1
Publication status	Published - 2001 Apr 2

Keywords

Apoptosis
Myasthenia gravis
NFkappaB
STAM
Thymus
c-myc

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(01)00252-1

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title = "Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients",

abstract = "The thymus is a critical organ for the elimination of autoreactive T cells by apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c-myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c-myc and max, were markedly reduced in MG thymuses. These results indicate that c-myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed.",

keywords = "Apoptosis, Myasthenia gravis, NFkappaB, STAM, Thymus, c-myc",

author = "T. Nagata and H. Onodera and M. Ohuchi and Y. Suzuki and H. Tago and Kazuo Fujihara and N. Ishii and K. Sugamura and Y. Shoji and M. Handa and K. Tabayashi and Y. Itoyama",

note = "Funding Information: This research was supported by grants-in-aid for Scientific Research (B, 10470152) from the Ministry of Education, Science, and Culture. We thank Mr. Brent Bell for reading the manuscript.",

year = "2001",

month = apr,

day = "2",

doi = "10.1016/S0165-5728(01)00252-1",

language = "English",

volume = "115",

pages = "199--202",

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TY - JOUR

T1 - Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients

AU - Nagata, T.

AU - Onodera, H.

AU - Ohuchi, M.

AU - Suzuki, Y.

AU - Tago, H.

AU - Fujihara, Kazuo

AU - Ishii, N.

AU - Sugamura, K.

AU - Shoji, Y.

AU - Handa, M.

AU - Tabayashi, K.

AU - Itoyama, Y.

N1 - Funding Information: This research was supported by grants-in-aid for Scientific Research (B, 10470152) from the Ministry of Education, Science, and Culture. We thank Mr. Brent Bell for reading the manuscript.

PY - 2001/4/2

Y1 - 2001/4/2

N2 - The thymus is a critical organ for the elimination of autoreactive T cells by apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c-myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c-myc and max, were markedly reduced in MG thymuses. These results indicate that c-myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed.

AB - The thymus is a critical organ for the elimination of autoreactive T cells by apoptosis. We studied the expression of apoptosis-associated genes, bcl-xL, bad, caspase-3, and c-myc family genes in myasthenia gravis (MG) thymuses. We observed that the mRNA levels of myc family genes, c-myc and max, were markedly reduced in MG thymuses. These results indicate that c-myc-mediated signaling is abnormal in MG thymuses. The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed.

KW - Apoptosis

KW - Myasthenia gravis

KW - NFkappaB

KW - STAM

KW - Thymus

KW - c-myc

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U2 - 10.1016/S0165-5728(01)00252-1

DO - 10.1016/S0165-5728(01)00252-1

M3 - Article

C2 - 11282171

AN - SCOPUS:0035795041

SN - 0165-5728

VL - 115

SP - 199

EP - 202

JO - Advances in Neuroimmunology

JF - Advances in Neuroimmunology

IS - 1-2

ER -

Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients

Abstract

Keywords

ASJC Scopus subject areas

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