Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis

Mohamed Abdel Shafee, Koji Fukuda, Yuji Wakayama, Makoto Nakano, Masateru Kondo, Yuhi Hasebe, Akiko Kawana, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


Background: Predictors of ventricular arrhythmias (VA) in patients with cardiac sarcoidosis (CS) remain unclear. Methods and results: We examined 61 consecutive CS patients who were admitted to our hospital from April 2002 to March 2012 with a mean follow-up period of 45 ± 31 months for the relationship between delayed enhancement on cardiac magnetic resonance imaging (DE-MRI) and VA or a composite endpoint, including VA, heart failure hospitalization, and cardiovascular mortality. Although there was no significant difference in baseline clinical characteristics between patients with VA and those without it, the former group was characterized as compared with the latter by lower left ventricular (LV) ejection fraction (p<0.05), larger LV systolic/diastolic dimensions (both p<0.05), and a significant association with DE-MRI (p<0.05). Furthermore, the patients with DE-MRI (n=26), as compared with those without it (n=11), had a significantly higher composite endpoint event rate (41% vs. 0%, p<0.05) and a trend toward higher VA (29% vs. 0%, p=0.12). Univariate analysis also showed that impaired LV systolic function was significantly associated with composite events on follow-up. Conclusions: These results indicate that the presence of DE-MRI is a significant predictor of VA events and poor outcome in CS patients.

Original languageEnglish
Pages (from-to)448-453
Number of pages6
JournalJournal of cardiology
Issue number6
Publication statusPublished - 2012 Dec


  • Cardiomyopathies
  • Magnetic resonance imaging
  • Other
  • Prognosis
  • Ventricular arrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis'. Together they form a unique fingerprint.

Cite this