Delayed wound healing by treatment of rapamycin and the effect of growth factors

Ayumi Yoshizaki, Yoshihide Asano, Koichi Yanaba, Shinichi Sato

Research output: Contribution to journalArticlepeer-review

Abstract

Rapamycin, a novel macrolide immunosuppressive drug, is increasingly used as an agent for post-transplant immunosuppression and treatment of autoimmune disease. Rapamycin inhibits mammalian target of rapamycin resulting in delayed wound healing. This delayed wound healing was normalized by treatment with basic fibroblast growth factor. This indicates that basic fibroblast growth factor plays an important and critical role in the rapamycin-induced delayed wound healing process.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalSkin Research
Volume11
Issue numberSUPPL. 17
Publication statusPublished - 2012 Mar

Keywords

  • Basic fibroblast growth factor
  • Cell adhesion molecules
  • Inflammatory cells
  • Rapamycin
  • Wound healing

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