TY - JOUR
T1 - Demonstration of antigen-specific immune response against Streptococcus sanguis
AU - Ishii, Norihisa
AU - Isogai, Emiko
AU - Yamakawa, Yuko
AU - Nakajima, Hiroshi
AU - Ohno, Shigeaki
AU - Isogai, Hiroshi
AU - Hayashi, Shunji
AU - Yokota, Kenji
AU - Oguma, Keiji
PY - 1993/6
Y1 - 1993/6
N2 - The genetic control of Streptococcus sanguis antigen response was studied. Mice sensitized with inactivated S. sanguis organisms antigen-injected at the base of the tail developed footpad swelling. Those with an I-Ak,q,r region of H-2 showed a strong footpad response, whereas those with an I-Ab,d,s region showed a weak response to S. sanguis cell wall antigen. Footpad response was mediated by CD4+, 8- T cells by using in vitro monoclonal antibody treatment. Similar evidence of genetic control was obtained with an in vitro T cell proliferation assay. However, quantitation of antibodies against S. sanguis showed that antibody production was not controlled by H-2. These results indicated that both in vivo footpad swelling and in vitro T cell proliferation responses were functions of helper (CD3+, 4+, 8-) T cells and controlled by the I-A region of H-2.
AB - The genetic control of Streptococcus sanguis antigen response was studied. Mice sensitized with inactivated S. sanguis organisms antigen-injected at the base of the tail developed footpad swelling. Those with an I-Ak,q,r region of H-2 showed a strong footpad response, whereas those with an I-Ab,d,s region showed a weak response to S. sanguis cell wall antigen. Footpad response was mediated by CD4+, 8- T cells by using in vitro monoclonal antibody treatment. Similar evidence of genetic control was obtained with an in vitro T cell proliferation assay. However, quantitation of antibodies against S. sanguis showed that antibody production was not controlled by H-2. These results indicated that both in vivo footpad swelling and in vitro T cell proliferation responses were functions of helper (CD3+, 4+, 8-) T cells and controlled by the I-A region of H-2.
KW - Antibody production
KW - Footpad swelling
KW - Genetic control
KW - Helper T cells
KW - Streptococcus sanguis
KW - T cell proliferation
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U2 - 10.1016/0923-1811(93)90765-H
DO - 10.1016/0923-1811(93)90765-H
M3 - Article
C2 - 7694648
AN - SCOPUS:0027301622
SN - 0923-1811
VL - 5
SP - 182
EP - 189
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
IS - 3
ER -