Dependence of pulpal blood-flow responses on baseline blood-flow in the cat

T. Sasano, N. Shoji, S. Kuriwada-Satoh, M. Iikubo, H. Izumi, K. Karita

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


It has been shown earlier that electrical stimulation of the distal cut end of the inferior alveolar nerve (IAN) in the cat evokes three different patterns of pulpal blood-flow (PBF) response in the ipsilateral mandibular canine tooth (a decrease, a biphasic response, or an increase). The response to a given stimulus sometimes changed to another pattern even in one and the same experimental animal during the course of the experiment. It is known that the evoked decrease is due to activation of the sympathetics and that the increase is due to antidromic activation of sensory fibres; but, it is unknown why the response varies so much. It is hypothesised that the baseline blood-flow (BBF) modulates vasomotor responses in the dental pulp. To test this hypothesis, the effects of BBF on PBF responses elicited by the IAN stimulation mentioned above were investigated. Dynamic changes in PBF in cat mandibular canine teeth were elicited by electrical stimulation of the distal cut end of the IAN, at various BBF, with blood-flow monitored by laser Doppler flowmetry. The amplitude of the PBF vasodilator response increased as BBF was adjusted downwards (by cooling the tooth). In contrast, the amplitude of the PBF vasoconstrictor response increased as the BBF rose. Vasodilator responses could be transformed into vasoconstrictor responses, and vice versa, by alterations in the BBF. No systemic blood-pressure changes were elicited throughout the experiment. These results indicate that a consideration of baseline vascular tone is important, whenever the size of PBF responses to various stimuli is discussed or calculated.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalArchives of Oral Biology
Issue number2
Publication statusPublished - 2002


  • Antidromic vasodilatation
  • Baseline vascular tone
  • Pulpal blood-flow
  • Sympathetic vasoconstriction
  • Vasomotor responses


Dive into the research topics of 'Dependence of pulpal blood-flow responses on baseline blood-flow in the cat'. Together they form a unique fingerprint.

Cite this