Depressive state and chronic fatigue in multiple sclerosis and neuromyelitis optica

Tetsuya Akaishi, Ichiro Nakashima, Tatsuro Misu, Kazuo Fujihara, Masashi Aoki

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Depression and chronic fatigue are frequently present in multiple sclerosis (MS); however, the prevalence rates have not been investigated in neuromyelitis optica (NMO). Thirty-nine consecutive NMO and 75 MS patients were compared using self-rating questionnaires for depressive states, daily activity, and fatigue, as well as serum carnitine levels. A subgroup of patients with low carnitine levels were re-evaluated regarding depression and fatigue after levocarnitine treatment. Depression and fatigue were equally prevalent in MS and NMO and were strongly correlated with one another. Measurement of the serum carnitine levels and the administration of levocarnitine did not appear to be beneficial.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalJournal of Neuroimmunology
Publication statusPublished - 2015 Jun 15


  • Carnitine
  • Depression
  • Fatigue
  • Levocarnitine
  • Neuromyelitis optica


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