Design and function of amylose-poly(L-lysine) conjugate nanogels

Junko Tamada; Mio Yamazaki; Nobuyuki Morimoto; Longliang Wu; Kaoru Takada; Sung Won Choi; Atsushi Maruyama; Kazunari Akiyosh

Design and function of amylose-poly(L-lysine) conjugate nanogels

Junko Tamada, Mio Yamazaki, Nobuyuki Morimoto, Longliang Wu, Kaoru Takada, Sung Won Choi, Atsushi Maruyama, Kazunari Akiyosh

Research output: Contribution to conference › Paper › peer-review

Abstract

Poly(L-lysine) (PLL) can interact with DNA and forms stable polyion complex (PIC). Novel amylose primers those consist of maltopentaose (MP) and PLL or cholesteryl PLL were designed. 30% of MP substituted PLL (MaPLL, CH-MaPLL) were synthesized by reductive animation reaction. The MP-PLL and CH-MaPLL copolymers were enzymatically polymerized and the degree of polymerization (DP) was linearly increased in accordance to the polymerization time. Positive charge of the conjugates was shielded with increasing the degree of polymerization. Interaction of the conjugates with DNA was investigated.

Original language	English
Pages	4808
Number of pages	1
Publication status	Published - 2006
Externally published	Yes
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: 2006 Sept 20 → 2006 Sept 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	06/9/20 → 06/9/22

Keywords

Amylose
Enzymatic polymerization
Nucleic chaperone
Poly(l-lysine)

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Design and function of amylose-poly(L-lysine) conjugate nanogels",

abstract = "Poly(L-lysine) (PLL) can interact with DNA and forms stable polyion complex (PIC). Novel amylose primers those consist of maltopentaose (MP) and PLL or cholesteryl PLL were designed. 30% of MP substituted PLL (MaPLL, CH-MaPLL) were synthesized by reductive animation reaction. The MP-PLL and CH-MaPLL copolymers were enzymatically polymerized and the degree of polymerization (DP) was linearly increased in accordance to the polymerization time. Positive charge of the conjugates was shielded with increasing the degree of polymerization. Interaction of the conjugates with DNA was investigated.",

keywords = "Amylose, Enzymatic polymerization, Nucleic chaperone, Poly(l-lysine)",

author = "Junko Tamada and Mio Yamazaki and Nobuyuki Morimoto and Longliang Wu and Kaoru Takada and Choi, {Sung Won} and Atsushi Maruyama and Kazunari Akiyosh",

year = "2006",

language = "English",

pages = "4808",

}

TY - CONF

T1 - Design and function of amylose-poly(L-lysine) conjugate nanogels

AU - Tamada, Junko

AU - Yamazaki, Mio

AU - Morimoto, Nobuyuki

AU - Wu, Longliang

AU - Takada, Kaoru

AU - Choi, Sung Won

AU - Maruyama, Atsushi

AU - Akiyosh, Kazunari

PY - 2006

Y1 - 2006

N2 - Poly(L-lysine) (PLL) can interact with DNA and forms stable polyion complex (PIC). Novel amylose primers those consist of maltopentaose (MP) and PLL or cholesteryl PLL were designed. 30% of MP substituted PLL (MaPLL, CH-MaPLL) were synthesized by reductive animation reaction. The MP-PLL and CH-MaPLL copolymers were enzymatically polymerized and the degree of polymerization (DP) was linearly increased in accordance to the polymerization time. Positive charge of the conjugates was shielded with increasing the degree of polymerization. Interaction of the conjugates with DNA was investigated.

AB - Poly(L-lysine) (PLL) can interact with DNA and forms stable polyion complex (PIC). Novel amylose primers those consist of maltopentaose (MP) and PLL or cholesteryl PLL were designed. 30% of MP substituted PLL (MaPLL, CH-MaPLL) were synthesized by reductive animation reaction. The MP-PLL and CH-MaPLL copolymers were enzymatically polymerized and the degree of polymerization (DP) was linearly increased in accordance to the polymerization time. Positive charge of the conjugates was shielded with increasing the degree of polymerization. Interaction of the conjugates with DNA was investigated.

KW - Amylose

KW - Enzymatic polymerization

KW - Nucleic chaperone

KW - Poly(l-lysine)

UR - http://www.scopus.com/inward/record.url?scp=33846138082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846138082&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846138082

SP - 4808

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Design and function of amylose-poly(L-lysine) conjugate nanogels

Abstract

Other

Keywords

ASJC Scopus subject areas

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