TY - JOUR
T1 - Design of highly efficient and selective transfer reaction of nitrosyl group to dC and dMC resulting in specific deamination
AU - Ali, Md Monsur
AU - Nagatsugi, Fumi
AU - Nakayama, Shizuka
AU - Alam, Md Rowshon
AU - Kawasaki, Takeshi
AU - Sasaki, Shigeki
PY - 2005
Y1 - 2005
N2 - Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific deamination.
AB - Nitric oxide (NO) is an important endogenous regulatory molecule, and S-nitrosothiols are believed to play a significant role in NO storage, transport, and delivery. Based on the ability to generate NO in vivo, S-nitrosothiols can be used as therapeutic drugs. In this study, we have developed an innovative method for sequence- and base-specific delivery of NO to a specific site of DNA followed by specific deamination.
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U2 - 10.1081/NCN-200060312
DO - 10.1081/NCN-200060312
M3 - Article
C2 - 16248023
AN - SCOPUS:26644433454
SN - 1525-7770
VL - 24
SP - 721
EP - 724
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 5-7
ER -