Design of novel bioactive materials through organic modification of calcium silicate

Chikara Ohtsuki, Toshiki Miyazaki, Masanobu Kamitakahara, Masao Tanihara

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Bioactive ceramics have attractive feature for bone repair such as direct bone-bonding in the body. However their clinical application is limited to low loaded portions due to their inappropriate mechanical performances such as higher brittleness and lower flexibility than natural bone. The essential condition for artificial materials to show bioactivity is formation of bone-like apatite on their surfaces in body environment. This apatite formation is triggered by silanol (Si-OH) group on the material surfaces and release of Ca2+. These findings bring us an idea that novel bioactive materials with high flexibility can be designed by organic modification of calcium silicate. We synthesized organic-inorganic hybrids from organic polymers including 2-hydroxyethylmethacrylate (HEMA), starch and alginate by modification with alkoxysilane and calcium chloride. The hybrids formed apatite on their surfaces in simulated body fluid (SBF, Kokubo solution). Such a modification was also effective for providing conventional polymethylmethacrylate (PMMA)-based bone cement with bioactivity.

Original languageEnglish
Pages (from-to)1527-1533
Number of pages7
JournalJournal of the European Ceramic Society
Issue number2-3
Publication statusPublished - 2007
Externally publishedYes


  • Apatite
  • Bioactivity
  • Biomedical applications
  • Nanocomposites
  • Silicate

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry


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