Detection of single magnetic bead for biological applications using an InAs quantum-well micro-Hall sensor

Goran Mihajlović; Peng Xiong; Stephan Von Molnár; Keita Ohtani; Hideo Ohno; Mark Field; Gerard J. Sullivan

doi:10.1063/1.2043238

Detection of single magnetic bead for biological applications using an InAs quantum-well micro-Hall sensor

Goran Mihajlović, Peng Xiong, Stephan Von Molnár, Keita Ohtani, Hideo Ohno, Mark Field, Gerard J. Sullivan

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42 Citations (Scopus)

Abstract

Room-temperature detection of a single commercial superparamagnetic bead (1.2 μm in diameter) suitable for biological applications has been realized using an InAs quantum-well micro-Hall sensor. The detection was demonstrated using phase-sensitive detection on a single Hall cross as well as in a Hall gradiometry setup. The high signal to noise ratio, obtained in both configurations, promises detection of single nanometer-size particles by further miniaturization of the device to submicron dimensions.

Original language	English
Article number	112502
Journal	Applied Physics Letters
Volume	87
Issue number	11
DOIs	https://doi.org/10.1063/1.2043238
Publication status	Published - 2005 Sept 12

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.2043238

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title = "Detection of single magnetic bead for biological applications using an InAs quantum-well micro-Hall sensor",

abstract = "Room-temperature detection of a single commercial superparamagnetic bead (1.2 μm in diameter) suitable for biological applications has been realized using an InAs quantum-well micro-Hall sensor. The detection was demonstrated using phase-sensitive detection on a single Hall cross as well as in a Hall gradiometry setup. The high signal to noise ratio, obtained in both configurations, promises detection of single nanometer-size particles by further miniaturization of the device to submicron dimensions.",

author = "Goran Mihajlovi{\'c} and Peng Xiong and {Von Moln{\'a}r}, Stephan and Keita Ohtani and Hideo Ohno and Mark Field and Sullivan, {Gerard J.}",

note = "Funding Information: The authors would like to acknowledge the help of Dr. Yongqing Li in the initial stage of the project, and Dr. Jens M{\"u}ller for fruitful discussions on noise characterization. This work has been supported by NSF NIRT Grant ECS-0210332 and a FSU Research Foundation PEG Grant.",

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AU - Mihajlović, Goran

AU - Xiong, Peng

AU - Von Molnár, Stephan

AU - Ohtani, Keita

AU - Ohno, Hideo

AU - Field, Mark

AU - Sullivan, Gerard J.

N1 - Funding Information: The authors would like to acknowledge the help of Dr. Yongqing Li in the initial stage of the project, and Dr. Jens Müller for fruitful discussions on noise characterization. This work has been supported by NSF NIRT Grant ECS-0210332 and a FSU Research Foundation PEG Grant.

PY - 2005/9/12

Y1 - 2005/9/12

N2 - Room-temperature detection of a single commercial superparamagnetic bead (1.2 μm in diameter) suitable for biological applications has been realized using an InAs quantum-well micro-Hall sensor. The detection was demonstrated using phase-sensitive detection on a single Hall cross as well as in a Hall gradiometry setup. The high signal to noise ratio, obtained in both configurations, promises detection of single nanometer-size particles by further miniaturization of the device to submicron dimensions.

AB - Room-temperature detection of a single commercial superparamagnetic bead (1.2 μm in diameter) suitable for biological applications has been realized using an InAs quantum-well micro-Hall sensor. The detection was demonstrated using phase-sensitive detection on a single Hall cross as well as in a Hall gradiometry setup. The high signal to noise ratio, obtained in both configurations, promises detection of single nanometer-size particles by further miniaturization of the device to submicron dimensions.

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Detection of single magnetic bead for biological applications using an InAs quantum-well micro-Hall sensor

Abstract

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