TY - JOUR
T1 - Development and evaluation of ultrasound-facilitated drug delivery device
AU - Inoue, Kenji
AU - Sato, Aya
AU - Saito, Ryuta
AU - Wenting, Jia
AU - Okuno, Saori
AU - Ohashi, Yuji
AU - Kamada, Kei
AU - Yoshikawa, Akira
AU - Tominaga, Teiji
N1 - Funding Information:
This research was (partially) supported by the Department of Clinical Research and Trials from the Japan Agency for Medical Research and Development (AMED).
Publisher Copyright:
© 2018 The Japan Society of Applied Physics.
PY - 2018/11
Y1 - 2018/11
N2 - We developed a new ultrasound-facilitated delivery (UFD) device with a drug infusion sapphire needle enabling real-time magnetic resonance imaging (MRI) observation and an ultrasound piezoelectric transducer (drive frequency: 260 kHz) with an effective structure for increasing drug diffusion. The sapphire needle (outside diameter: 0.6 mm, inside diameter: 0.3 mm, length: 150 mm) was grown by a micro-pulling-down method. The transducer is composed of two-stacked layers of lead zirconate titanate (PZT) on a brass base. The sound pressure distribution of the developed UFD device in water was measured with a miniature probe hydrophone, showing good agreement with the value simulated by the finite element method (FEM) analysis. The developed UFD device demonstrated high efficiency and reliability of drug diffusion, exhibiting an 8.5% increase in the volume of drug diffusion with 80% higher reproducibility and 66% lower driving voltage than the previous device. Consequently, the operating temperature of the new UFD device was decreased from 60 °C to room temperature.
AB - We developed a new ultrasound-facilitated delivery (UFD) device with a drug infusion sapphire needle enabling real-time magnetic resonance imaging (MRI) observation and an ultrasound piezoelectric transducer (drive frequency: 260 kHz) with an effective structure for increasing drug diffusion. The sapphire needle (outside diameter: 0.6 mm, inside diameter: 0.3 mm, length: 150 mm) was grown by a micro-pulling-down method. The transducer is composed of two-stacked layers of lead zirconate titanate (PZT) on a brass base. The sound pressure distribution of the developed UFD device in water was measured with a miniature probe hydrophone, showing good agreement with the value simulated by the finite element method (FEM) analysis. The developed UFD device demonstrated high efficiency and reliability of drug diffusion, exhibiting an 8.5% increase in the volume of drug diffusion with 80% higher reproducibility and 66% lower driving voltage than the previous device. Consequently, the operating temperature of the new UFD device was decreased from 60 °C to room temperature.
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U2 - 10.7567/JJAP.57.11UD07
DO - 10.7567/JJAP.57.11UD07
M3 - Article
AN - SCOPUS:85057144033
SN - 0021-4922
VL - 57
JO - Japanese Journal of Applied Physics
JF - Japanese Journal of Applied Physics
IS - 11
M1 - 11UD07
ER -