TY - GEN
T1 - Development of a method for cell delivery into the subretinal space using biodegradable nanosheets
AU - Yamashita, Kazuya
AU - Kojima, Hideto
AU - Nagai, Nobuhiro
AU - Abe, Toshiaki
AU - Kaji, Hirokazu
N1 - Publisher Copyright:
© 2020 CBMS-0001
PY - 2020
Y1 - 2020
N2 - We investigated a minimally invasive and effective method for cell transplantation into the subretinal space. A biodegradable nanosheet as cell scaffold was fabricated from polycaprolactone (PCL) and collagen as low inflammatory materials and had sufficient strength and flexibility. Cell/nanosheet constructs were prepared by culturing cells on the nanosheets in a monolayer and injected into the subretinal space through the sclera of rat with a syringe needle. The cell/nanosheet construct was successively delivered into the subretinal space. This method holds great promise for transplantation of monolayer cells and for the development of local cell delivery systems.
AB - We investigated a minimally invasive and effective method for cell transplantation into the subretinal space. A biodegradable nanosheet as cell scaffold was fabricated from polycaprolactone (PCL) and collagen as low inflammatory materials and had sufficient strength and flexibility. Cell/nanosheet constructs were prepared by culturing cells on the nanosheets in a monolayer and injected into the subretinal space through the sclera of rat with a syringe needle. The cell/nanosheet construct was successively delivered into the subretinal space. This method holds great promise for transplantation of monolayer cells and for the development of local cell delivery systems.
KW - Cell delivery system
KW - Cell scaffold
KW - Cell transplantation
KW - Polymeric membrane
KW - Regenerative medicine
UR - http://www.scopus.com/inward/record.url?scp=85098277902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85098277902&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85098277902
T3 - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1264
EP - 1265
BT - MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
Y2 - 4 October 2020 through 9 October 2020
ER -