Development of a spheroid-permeable polymer

Masaya Yamamoto, Nobuyuki Morimoto

Research output: Contribution to journalArticlepeer-review

Abstract

Spheroids have attracted much attention in medical research as a tool to understand both disease mechanisms and drug actions in culture. Cell-cell and/or cell-extracellular matrices DDS interactions seen in spheroids allow cells to mimic in vivo cellular microenvironments, resulting in recapitulating in vivo-like cell functions in culture. However, the microenvironments could also function as a barrier to deliver drugs to cells in spheroids. To tackle this drawback, a sulfobetaine polymer was developed as a spheroid-permeable polymer. In this article, the enhanced anticancer activity of anticancer drugs by conjugation with the spheroid-permeable polymer was introduced.

Original languageEnglish
Pages (from-to)248-255
Number of pages8
JournalDrug Delivery System
Volume36
Issue number4
DOIs
Publication statusPublished - 2021

Keywords

  • Cell aggregate
  • Spheroid
  • Spheroid-permeable polymer
  • Sulfobetaine polymer

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