Development of Behçet's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan

Takayuki Kimura, Yoshihide Asano, Mizuho Yamamoto, Makoto Sugaya, Shinichi Sato

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3 Citations (Scopus)

Abstract

We herein report a 32-year-old Caucasian woman with human leukocyte antigen (HLA)-B51 who developed Behçet's disease after immigration to Japan. She was born and raised in Finland and had never experienced any clinical symptoms related to Behçet's disease before immigration to Japan. None of her family members in Finland had similar problems. Two years after the immigration, she developed typical clinical symptoms of Behçet's disease. This report strongly supports the canonical notion that the interaction of genetic factors, such as HLA-B51, with environmental factors specific to the countries in the Silk Road area, including Japan, may play a pivotal role in the pathogenesis of this disorder.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalJournal of Dermatology
Volume38
Issue number6
DOIs
Publication statusPublished - 2011 Jun

Keywords

  • Behçet's disease
  • Caucasian
  • environmental factors
  • human leukocyte antigen B51
  • Silk Road area

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