Development of drug carriers for therapy of arterioscleosis

Kenjiro Ikuta, Takeshi Mori, Takuro Niidome, Hiroaki Shimokawa, Yoshiki Katayama

Research output: Contribution to conferencePaperpeer-review


The vascular endothelium dysfunction often leads to a cardiovascular disease such as arteriosclerosis. Therefore, detection and evaluation of vascular endothelium disorder in early stage would be very important for the effective diagnosis and therapy. We found that the structural analogues of Evans Blue adsorb to a vascular endothelium denuded region. Thus, we synthesized a polymeric drug carrier which consisted of amphipathic polymer and sensing unit (Evans Blue analogue) and evaluated the characteristics of the polymeric carriers. And then a extracted porcine aorta which was removed endothelial cell in left half area was treated with the micelle solution to evaluate a targeting ability of the micelle.

Original languageEnglish
Number of pages2
Publication statusPublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: 2006 Sept 202006 Sept 22


Other55th Society of Polymer Science Japan Symposium on Macromolecules


  • Arteriosclerosis
  • Drug delivery systems
  • Endothelium dysfunction
  • Evans Blue analogue

ASJC Scopus subject areas

  • Engineering(all)


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