Development of human graafian follicles following transplantation of human ovarian tissue into NOD/SCID/γcnull mice

Yukihiro Terada; Yumi Terunuma-Sato; Tomoko Kakoi-yoshimoto; Hisataka Hasegawa; Tomohisa Ugajin; Yoshio Koyanagi; Mamoru Ito; Takashi Murakami; Hironobu Sasano; Nobuo Yaegashi; Kunihiro Okamura

doi:10.1111/j.1600-0897.2008.00653.x

Development of human graafian follicles following transplantation of human ovarian tissue into NOD/SCID/γcnull mice

Yukihiro Terada, Yumi Terunuma-Sato, Tomoko Kakoi-yoshimoto, Hisataka Hasegawa, Tomohisa Ugajin, Yoshio Koyanagi, Mamoru Ito, Takashi Murakami, Hironobu Sasano, Nobuo Yaegashi, Kunihiro Okamura

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Problem: Transplantation of human ovarian cortex into host mice may permit various kinds of challenges in reproductive medicine. A novel immunodeficient mouse strain (NOD/SCID/γcnull: NOG) has been developed as a host of transplantation of human tissue. Method of study: Human ovarian cortex was transplanted into various sites of NOG mice and human follicular development was examined by immunohistochemistry. Results: Transplantation of human ovarian tissue into NOG mice resulted in approximately similar tissue survival and follicle growth as did transplantation into non-obese diabetic-severe combined immunodeficient mice. The human Graafian follicule from NOG mouse expressed the same steroidogenic enzymes as observed in human Graafian follicles, which developed in the human body. The NOG mice's ovarian bursa was better placed for transplantation than the back skin or kidney capsule. Conclusion: These results represent the successful generation and biological confirmation of the human Graafian follicles from the human ovarian cortex in the NOG mice.

Original language	English
Pages (from-to)	534-540
Number of pages	7
Journal	American Journal of Reproductive Immunology
Volume	60
Issue number	6
DOIs	https://doi.org/10.1111/j.1600-0897.2008.00653.x
Publication status	Published - 2008

Keywords

Graafian follicle
Human ovarian cortex
Mice
NOG
Ovarian bursa
Xenotransplantation

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Reproductive Medicine
Obstetrics and Gynaecology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0897.2008.00653.x

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Terada, Y., Terunuma-Sato, Y., Kakoi-yoshimoto, T., Hasegawa, H., Ugajin, T., Koyanagi, Y., Ito, M., Murakami, T., Sasano, H., Yaegashi, N., & Okamura, K. (2008). Development of human graafian follicles following transplantation of human ovarian tissue into NOD/SCID/γcnull mice. American Journal of Reproductive Immunology, 60(6), 534-540. https://doi.org/10.1111/j.1600-0897.2008.00653.x

Terada, Y, Terunuma-Sato, Y, Kakoi-yoshimoto, T, Hasegawa, H, Ugajin, T, Koyanagi, Y, Ito, M, Murakami, T, Sasano, H, Yaegashi, N & Okamura, K 2008, 'Development of human graafian follicles following transplantation of human ovarian tissue into NOD/SCID/γcnull mice', American Journal of Reproductive Immunology, vol. 60, no. 6, pp. 534-540. https://doi.org/10.1111/j.1600-0897.2008.00653.x

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abstract = "Problem: Transplantation of human ovarian cortex into host mice may permit various kinds of challenges in reproductive medicine. A novel immunodeficient mouse strain (NOD/SCID/γcnull: NOG) has been developed as a host of transplantation of human tissue. Method of study: Human ovarian cortex was transplanted into various sites of NOG mice and human follicular development was examined by immunohistochemistry. Results: Transplantation of human ovarian tissue into NOG mice resulted in approximately similar tissue survival and follicle growth as did transplantation into non-obese diabetic-severe combined immunodeficient mice. The human Graafian follicule from NOG mouse expressed the same steroidogenic enzymes as observed in human Graafian follicles, which developed in the human body. The NOG mice's ovarian bursa was better placed for transplantation than the back skin or kidney capsule. Conclusion: These results represent the successful generation and biological confirmation of the human Graafian follicles from the human ovarian cortex in the NOG mice.",

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AU - Terunuma-Sato, Yumi

AU - Kakoi-yoshimoto, Tomoko

AU - Hasegawa, Hisataka

AU - Ugajin, Tomohisa

AU - Koyanagi, Yoshio

AU - Ito, Mamoru

AU - Murakami, Takashi

AU - Sasano, Hironobu

AU - Yaegashi, Nobuo

AU - Okamura, Kunihiro

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N2 - Problem: Transplantation of human ovarian cortex into host mice may permit various kinds of challenges in reproductive medicine. A novel immunodeficient mouse strain (NOD/SCID/γcnull: NOG) has been developed as a host of transplantation of human tissue. Method of study: Human ovarian cortex was transplanted into various sites of NOG mice and human follicular development was examined by immunohistochemistry. Results: Transplantation of human ovarian tissue into NOG mice resulted in approximately similar tissue survival and follicle growth as did transplantation into non-obese diabetic-severe combined immunodeficient mice. The human Graafian follicule from NOG mouse expressed the same steroidogenic enzymes as observed in human Graafian follicles, which developed in the human body. The NOG mice's ovarian bursa was better placed for transplantation than the back skin or kidney capsule. Conclusion: These results represent the successful generation and biological confirmation of the human Graafian follicles from the human ovarian cortex in the NOG mice.

AB - Problem: Transplantation of human ovarian cortex into host mice may permit various kinds of challenges in reproductive medicine. A novel immunodeficient mouse strain (NOD/SCID/γcnull: NOG) has been developed as a host of transplantation of human tissue. Method of study: Human ovarian cortex was transplanted into various sites of NOG mice and human follicular development was examined by immunohistochemistry. Results: Transplantation of human ovarian tissue into NOG mice resulted in approximately similar tissue survival and follicle growth as did transplantation into non-obese diabetic-severe combined immunodeficient mice. The human Graafian follicule from NOG mouse expressed the same steroidogenic enzymes as observed in human Graafian follicles, which developed in the human body. The NOG mice's ovarian bursa was better placed for transplantation than the back skin or kidney capsule. Conclusion: These results represent the successful generation and biological confirmation of the human Graafian follicles from the human ovarian cortex in the NOG mice.

KW - Graafian follicle

KW - Human ovarian cortex

KW - Mice

KW - NOG

KW - Ovarian bursa

KW - Xenotransplantation

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Development of human graafian follicles following transplantation of human ovarian tissue into NOD/SCID/γcnull mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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