Development of organocatalysis based on the molecular design of pyrrolidine-Brønsted acid catalysts

Susumu Saito; Norie Momiyama; Hisashi Yamamoto

doi:10.5059/yukigoseikyokaishi.66.774

Development of organocatalysis based on the molecular design of pyrrolidine-Brønsted acid catalysts

Susumu Saito, Norie Momiyama, Hisashi Yamamoto

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Proper design of amine-Bransted acid catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction. During the course of this study, two principal approaches have been implemented to create a new type of catalysis: One is derived from Brønsted acid and diamine; the other is pyrrolidine with tetrazole functionality. The developed amine-Brønsted acid catalysts have been found to effectively catalyze the direct aldol reaction of aldehyde, chloral and nitrosobenzene.

Original language	English
Pages (from-to)	774-784
Number of pages	11
Journal	Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Volume	66
Issue number	8
DOIs	https://doi.org/10.5059/yukigoseikyokaishi.66.774
Publication status	Published - 2008 Aug
Externally published	Yes

Keywords

Asymmetric synthesis
Direct aldol reaction
Hydrogen bonding
Pyrrolidine-Brønsted acid

ASJC Scopus subject areas

Organic Chemistry

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title = "Development of organocatalysis based on the molecular design of pyrrolidine-Br{\o}nsted acid catalysts",

abstract = "Proper design of amine-Bransted acid catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction. During the course of this study, two principal approaches have been implemented to create a new type of catalysis: One is derived from Br{\o}nsted acid and diamine; the other is pyrrolidine with tetrazole functionality. The developed amine-Br{\o}nsted acid catalysts have been found to effectively catalyze the direct aldol reaction of aldehyde, chloral and nitrosobenzene.",

keywords = "Asymmetric synthesis, Direct aldol reaction, Hydrogen bonding, Pyrrolidine-Br{\o}nsted acid",

author = "Susumu Saito and Norie Momiyama and Hisashi Yamamoto",

year = "2008",

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doi = "10.5059/yukigoseikyokaishi.66.774",

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AU - Saito, Susumu

AU - Momiyama, Norie

AU - Yamamoto, Hisashi

PY - 2008/8

Y1 - 2008/8

N2 - Proper design of amine-Bransted acid catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction. During the course of this study, two principal approaches have been implemented to create a new type of catalysis: One is derived from Brønsted acid and diamine; the other is pyrrolidine with tetrazole functionality. The developed amine-Brønsted acid catalysts have been found to effectively catalyze the direct aldol reaction of aldehyde, chloral and nitrosobenzene.

AB - Proper design of amine-Bransted acid catalysis has been shown to be effective for achieving high reactivity and selectivity in the asymmetric direct aldol reaction. During the course of this study, two principal approaches have been implemented to create a new type of catalysis: One is derived from Brønsted acid and diamine; the other is pyrrolidine with tetrazole functionality. The developed amine-Brønsted acid catalysts have been found to effectively catalyze the direct aldol reaction of aldehyde, chloral and nitrosobenzene.

KW - Asymmetric synthesis

KW - Direct aldol reaction

KW - Hydrogen bonding

KW - Pyrrolidine-Brønsted acid

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Development of organocatalysis based on the molecular design of pyrrolidine-Brønsted acid catalysts

Abstract

Keywords

ASJC Scopus subject areas

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