Development of the optical biopsy system for small experimental animals

Hidetoshi Sato; Yusuke Hattori; Yusuke Oshima; Yuichi Komachi; Takashi Katagiri; Toru Asakura; Toru Shimosegawa; Yuji Matsuura; Mitsunobu Miyagi; Gen'ichi Kanai; Nobuo Ura; Koji Masutani; Hideo Tashiro

doi:10.1117/12.645842

Development of the optical biopsy system for small experimental animals

Hidetoshi Sato, Yusuke Hattori, Yusuke Oshima, Yuichi Komachi, Takashi Katagiri, Toru Asakura, Toru Shimosegawa, Yuji Matsuura, Mitsunobu Miyagi, Gen'ichi Kanai, Nobuo Ura, Koji Masutani, Hideo Tashiro

MEN - Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Citations (Scopus)

Abstract

Development of the optical biopsy system for experimental small animals is in progress. A prototype of the system which consists of a miniaturized gastro endoscope unit and Raman probes has been completed by now. The system is developed to study a gastric cancer rat model. The endoscope is 2.5 mm in diameter and is equipped an imaging bundle fiber, illumination fibers, a channel and a mechanism to angle the probe head. The head of the Raman probe comes out through the channel and it is possible to aim the probe to the target watching on the monitor. The endoscope was inserted into the anaesthetized healthy rat under the breathing support. It was successfully observed inside of the stomach of the living rat and measured Raman spectra. The spectrum of blood vessels contains the strong contribution from lipids. The present results demonstrate high potential of the system in the in vivo Raman study using the rat model.

Original language	English
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DOIs	https://doi.org/10.1117/12.645842
Publication status	Published - 2006
Event	Optical Biopsy VI - San Jose, CA, United States Duration: 2006 Jan 24 → 2006 Jan 24

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	6091
ISSN (Print)	1605-7422

Other

Other	Optical Biopsy VI
Country/Territory	United States
City	San Jose, CA
Period	06/1/24 → 06/1/24

Keywords

Endoscope
Gastric cancer
In vivo
Noninvasive
Optical biopsy
Ramam spectroscopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.645842

Cite this

Sato, H., Hattori, Y., Oshima, Y., Komachi, Y., Katagiri, T., Asakura, T., Shimosegawa, T., Matsuura, Y., Miyagi, M., Kanai, G., Ura, N., Masutani, K., & Tashiro, H. (2006). Development of the optical biopsy system for small experimental animals. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE [60910H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6091). https://doi.org/10.1117/12.645842

Development of the optical biopsy system for small experimental animals. / Sato, Hidetoshi; Hattori, Yusuke; Oshima, Yusuke et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2006. 60910H (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6091).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sato, H, Hattori, Y, Oshima, Y, Komachi, Y, Katagiri, T, Asakura, T, Shimosegawa, T, Matsuura, Y, Miyagi, M, Kanai, G, Ura, N, Masutani, K & Tashiro, H 2006, Development of the optical biopsy system for small experimental animals. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE., 60910H, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 6091, Optical Biopsy VI, San Jose, CA, United States, 06/1/24. https://doi.org/10.1117/12.645842

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author = "Hidetoshi Sato and Yusuke Hattori and Yusuke Oshima and Yuichi Komachi and Takashi Katagiri and Toru Asakura and Toru Shimosegawa and Yuji Matsuura and Mitsunobu Miyagi and Gen'ichi Kanai and Nobuo Ura and Koji Masutani and Hideo Tashiro",

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AU - Hattori, Yusuke

AU - Oshima, Yusuke

AU - Komachi, Yuichi

AU - Katagiri, Takashi

AU - Asakura, Toru

AU - Shimosegawa, Toru

AU - Matsuura, Yuji

AU - Miyagi, Mitsunobu

AU - Kanai, Gen'ichi

AU - Ura, Nobuo

AU - Masutani, Koji

AU - Tashiro, Hideo

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N2 - Development of the optical biopsy system for experimental small animals is in progress. A prototype of the system which consists of a miniaturized gastro endoscope unit and Raman probes has been completed by now. The system is developed to study a gastric cancer rat model. The endoscope is 2.5 mm in diameter and is equipped an imaging bundle fiber, illumination fibers, a channel and a mechanism to angle the probe head. The head of the Raman probe comes out through the channel and it is possible to aim the probe to the target watching on the monitor. The endoscope was inserted into the anaesthetized healthy rat under the breathing support. It was successfully observed inside of the stomach of the living rat and measured Raman spectra. The spectrum of blood vessels contains the strong contribution from lipids. The present results demonstrate high potential of the system in the in vivo Raman study using the rat model.

AB - Development of the optical biopsy system for experimental small animals is in progress. A prototype of the system which consists of a miniaturized gastro endoscope unit and Raman probes has been completed by now. The system is developed to study a gastric cancer rat model. The endoscope is 2.5 mm in diameter and is equipped an imaging bundle fiber, illumination fibers, a channel and a mechanism to angle the probe head. The head of the Raman probe comes out through the channel and it is possible to aim the probe to the target watching on the monitor. The endoscope was inserted into the anaesthetized healthy rat under the breathing support. It was successfully observed inside of the stomach of the living rat and measured Raman spectra. The spectrum of blood vessels contains the strong contribution from lipids. The present results demonstrate high potential of the system in the in vivo Raman study using the rat model.

KW - Endoscope

KW - Gastric cancer

KW - In vivo

KW - Noninvasive

KW - Optical biopsy

KW - Ramam spectroscopy

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ER -

Development of the optical biopsy system for small experimental animals

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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