Development of the VAD inflow cannula with high stiffness using hybrid material

Yukino Kawase; Yusuke Inoue; Takashi Isoyama; Itsuro Saito; Toshiya Ono; Masami Sato; Shintaro Hara; Terumi Yurimoto; Li Xinyang; Haruka Murakami; Ayaka Tashiro; Erina Maeno; Ko Imachi; Hiroshi Kumagai; Yusuke Abe

doi:10.11239/jsmbe.52.O-243

Development of the VAD inflow cannula with high stiffness using hybrid material

Yukino Kawase, Yusuke Inoue, Takashi Isoyama, Itsuro Saito, Toshiya Ono, Masami Sato, Shintaro Hara, Terumi Yurimoto, Li Xinyang, Haruka Murakami, Ayaka Tashiro, Erina Maeno, Ko Imachi, Hiroshi Kumagai, Yusuke Abe

PreClinical Research Center

Research output: Contribution to journal › Article › peer-review

Abstract

The problem is wedge thrombus due to material of cannula. We thought that to solve the problem replace its' material with hybrid material. Hybrid blood inflow cannula is formed by implanting the core which consists of polyester velour and titanium conduit. Then, the cell component decellularized. By using this cannula, examined on chronic animal experiment with VAD in heterologous transplantation to evaluate the biocompatibility of cannula. As a result, the goat survived 53days without antithrombogenic agents and the cannula was connected to neighboring cardiac muscle smoothly and thrombos weren't formed. And the result of immunostaining, surface of cannula was coated with endothelial cells.

Original language	English
Pages (from-to)	O-243-O-244
Journal	Transactions of Japanese Society for Medical and Biological Engineering
Volume	52
DOIs	https://doi.org/10.11239/jsmbe.52.O-243
Publication status	Published - 2014 Aug 17

Keywords

Artificial material
Hybrid material
Tissue engineering
VAD inflow cannula

ASJC Scopus subject areas

Biomedical Engineering

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10.11239/jsmbe.52.O-243

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Kawase, Y., Inoue, Y., Isoyama, T., Saito, I., Ono, T., Sato, M., Hara, S., Yurimoto, T., Xinyang, L., Murakami, H., Tashiro, A., Maeno, E., Imachi, K., Kumagai, H., & Abe, Y. (2014). Development of the VAD inflow cannula with high stiffness using hybrid material. Transactions of Japanese Society for Medical and Biological Engineering, 52, O-243-O-244. https://doi.org/10.11239/jsmbe.52.O-243

Kawase, Y, Inoue, Y, Isoyama, T, Saito, I, Ono, T, Sato, M, Hara, S, Yurimoto, T, Xinyang, L, Murakami, H, Tashiro, A, Maeno, E, Imachi, K, Kumagai, H & Abe, Y 2014, 'Development of the VAD inflow cannula with high stiffness using hybrid material', Transactions of Japanese Society for Medical and Biological Engineering, vol. 52, pp. O-243-O-244. https://doi.org/10.11239/jsmbe.52.O-243

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abstract = "The problem is wedge thrombus due to material of cannula. We thought that to solve the problem replace its' material with hybrid material. Hybrid blood inflow cannula is formed by implanting the core which consists of polyester velour and titanium conduit. Then, the cell component decellularized. By using this cannula, examined on chronic animal experiment with VAD in heterologous transplantation to evaluate the biocompatibility of cannula. As a result, the goat survived 53days without antithrombogenic agents and the cannula was connected to neighboring cardiac muscle smoothly and thrombos weren't formed. And the result of immunostaining, surface of cannula was coated with endothelial cells.",

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AU - Kawase, Yukino

AU - Inoue, Yusuke

AU - Isoyama, Takashi

AU - Saito, Itsuro

AU - Ono, Toshiya

AU - Sato, Masami

AU - Hara, Shintaro

AU - Yurimoto, Terumi

AU - Xinyang, Li

AU - Murakami, Haruka

AU - Tashiro, Ayaka

AU - Maeno, Erina

AU - Imachi, Ko

AU - Kumagai, Hiroshi

AU - Abe, Yusuke

PY - 2014/8/17

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AB - The problem is wedge thrombus due to material of cannula. We thought that to solve the problem replace its' material with hybrid material. Hybrid blood inflow cannula is formed by implanting the core which consists of polyester velour and titanium conduit. Then, the cell component decellularized. By using this cannula, examined on chronic animal experiment with VAD in heterologous transplantation to evaluate the biocompatibility of cannula. As a result, the goat survived 53days without antithrombogenic agents and the cannula was connected to neighboring cardiac muscle smoothly and thrombos weren't formed. And the result of immunostaining, surface of cannula was coated with endothelial cells.

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KW - Tissue engineering

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Development of the VAD inflow cannula with high stiffness using hybrid material

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Keywords

ASJC Scopus subject areas

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