Developmental biology: Bone marrow stromal cells generate muscle cells and repair muscle degeneration

Mari Dezawa; Hiroto Ishikawa; Yutaka Itokazu; Tomoyuki Yoshihara; Mikio Hoshino; Shin Ichi Takeda; Chizuka Ide; Yo Ichi Nabeshima

doi:10.1126/science.1110364

Developmental biology: Bone marrow stromal cells generate muscle cells and repair muscle degeneration

Mari Dezawa, Hiroto Ishikawa, Yutaka Itokazu, Tomoyuki Yoshihara, Mikio Hoshino, Shin Ichi Takeda, Chizuka Ide, Yo Ichi Nabeshima

Research output: Contribution to journal › Article › peer-review

532 Citations (Scopus)

Abstract

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.

Original language	English
Pages (from-to)	314-317
Number of pages	4
Journal	Science
Volume	309
Issue number	5732
DOIs	https://doi.org/10.1126/science.1110364
Publication status	Published - 2005 Jul 8
Externally published	Yes

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AU - Dezawa, Mari

AU - Ishikawa, Hiroto

AU - Itokazu, Yutaka

AU - Yoshihara, Tomoyuki

AU - Hoshino, Mikio

AU - Takeda, Shin Ichi

AU - Ide, Chizuka

AU - Nabeshima, Yo Ichi

PY - 2005/7/8

Y1 - 2005/7/8

N2 - Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.

AB - Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.

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Developmental biology: Bone marrow stromal cells generate muscle cells and repair muscle degeneration

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