Developmental changes of gene expression in heme metabolic enzymes in rat placenta

Naomi Ihara, Reiko Akagi, Kohei Ejiri, Takafumi Kudo, Kazumichi Furuyama, Hiroyoshi Fujita

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Transcription levels of the non-specific δ-aminolevulinate synthase (ALAS-N) and heme oxygenase-1 (HO-1) in the placenta at the terminal stage of pregnancy were comparable to those in the female adult liver and in the spleen, respectively. Immunohistochemical studies demonstrated that both enzymes were exclusively expressed in the trophoblast. During gestation, transcript of ALAS-N slightly increased, while HO-1 mRNA significantly decreased. Induced acute fetal hypoxia resulted in an increase in ALAS-N mRNA and in a decrease in HO-1 mRNA. These findings indicate that placental heme metabolism is influenced by the oxygen supply. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalFEBS Letters
Issue number1-2
Publication statusPublished - 1998 Nov 13
Externally publishedYes


  • Fetus
  • Heme
  • Heme oxygenase
  • Hypoxia
  • Placenta
  • Trophoblast
  • δ-Aminolevulinate synthase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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