TY - JOUR
T1 - Diagnosis of prostate cancer and prostatitis using near infra-red fluorescent aginse/zns quantum dots
AU - Ncapayi, Vuyelwa
AU - Ninan, Neethu
AU - Lebepe, Thabang C.
AU - Parani, Sundararajan
AU - Girija, Aswathy Ravindran
AU - Bright, Richard
AU - Vasilev, Krasimir
AU - Maluleke, Rodney
AU - Tsolekile, Ncediwe
AU - Kodama, Tetsuya
AU - Oluwafemi, Oluwatobi S.
N1 - Funding Information:
Acknowledgments: The authors would like to thank National Research Foundation (N.R.F.), South Africa, the University of Johannesburg research committee (URC) and Faculty of Science research committee (FRC), and the Japan Student Services Organization (JASSO) under SA/Japan Bilateral for financial support.
Funding Information:
Funding: National Research Foundation (N.R.F), South Africa under Competitive Programme for Rated Researchers (CPRR), grant no 129290, the University of Johannesburg research committee (URC) and Faculty of Science research committee (FRC), and the Japan Student Services Organization (JASSO) under SA/Japan Bilateral.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.
AB - The link between the microbiome and cancer has led researchers to search for a potential probe for intracellular targeting of bacteria and cancer. Herein, we developed near infrared-emitting ternary AgInSe/ZnS quantum dots (QDs) for dual bacterial and cancer imaging. Briefly, water-soluble AgInSe/ZnS QDs were synthesized in a commercial kitchen pressure cooker. The as-synthesized QDs exhibited a spherical shape with a particle diameter of 4.5 ± 0.5 nm, and they were brightly fluorescent with a photoluminescence maximum at 705 nm. The QDs showed low toxicity against mouse mammary carcinoma (FM3A-Luc), mouse colon carcinoma (C26), malignant fibrous histiocytoma-like (KM-Luc/GFP) and prostate cancer cells, a greater number of accumulations in Staphylococcus aureus, and good cellular uptake in prostate cancer cells. This work is an excellent step towards using ternary QDs for diagnostic and guided therapy for prostate cancer.
KW - Bioimaging
KW - Gram-negative bacteria
KW - Gram-positive bacteria
KW - Near infra-red quantum dots
KW - Prostate cancer
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U2 - 10.3390/ijms222212514
DO - 10.3390/ijms222212514
M3 - Article
C2 - 34830396
AN - SCOPUS:85119250874
SN - 1422-0067
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 22
M1 - 12514
ER -
