TY - JOUR
T1 - Diagnostic accuracy of a modified subtraction coronary CT angiography method with short breath-holding time
T2 - A feasibility study
AU - Yoshioka, Kunihiro
AU - Tanaka, Ryoichi
AU - Takagi, Hidenobu
AU - Nagata, Kyouhei
AU - Chiba, Takuya
AU - Takeda, Kouta
AU - Ueda, Takanori
AU - Sugawara, Tsuyoshi
AU - Sasaki, Akinobu
AU - Ueyama, Yuta
AU - Kikuchi, Kei
AU - Sasaki, Tadashi
N1 - Funding Information:
This work was supported in part by the Japan Society for the Promotion of Science (JSPS KAKENHI, Grant Number JP26461803).
Publisher Copyright:
© 2016 The Authors.
PY - 2016
Y1 - 2016
N2 - Objective: To explore the feasibility and diagnostic accuracy of modified subtraction coronary CT angiography (CCTA) with short breath-holding time in patients who have limited breath-hold capability and severe coronary artery calcification. Methods: 11 patients with a coronary calcium score .400 underwent CCTA using a modified subtraction protocol. All patients were unable to hold their breath for more than 20 s. Subjective image quality using a four-point scale and the presence of significant (.50%) luminal stenosis were assessed for each calcified or stented segment on both conventional CCTA and modified subtraction CCTA images and compared with invasive coronary angiography (ICA) as the gold standard. Results: The mean breath-holding time was 13.060.9 s. A total of 35 calcified or stented coronary segments were evaluated. The average image quality was increased from 2.160.9 with conventional CCTA to 3.160.7 with subtraction CCTA (p,0.001). The segmentbased diagnostic accuracy for detecting significant stenosis according to ICA revealed an area under the receiver-operating characteristic curve of 0.722 for conventional CCTA and 0.892 for subtraction CCTA (p 5 0.036). Conclusion: Modified subtraction CCTA allows the breathholding time to be shortened to ,15 s. As compared with conventional CCTA, modified subtraction CCTA showed improvement in image quality and diagnostic accuracy in patients with limited breath-hold capability and severe calcification.
AB - Objective: To explore the feasibility and diagnostic accuracy of modified subtraction coronary CT angiography (CCTA) with short breath-holding time in patients who have limited breath-hold capability and severe coronary artery calcification. Methods: 11 patients with a coronary calcium score .400 underwent CCTA using a modified subtraction protocol. All patients were unable to hold their breath for more than 20 s. Subjective image quality using a four-point scale and the presence of significant (.50%) luminal stenosis were assessed for each calcified or stented segment on both conventional CCTA and modified subtraction CCTA images and compared with invasive coronary angiography (ICA) as the gold standard. Results: The mean breath-holding time was 13.060.9 s. A total of 35 calcified or stented coronary segments were evaluated. The average image quality was increased from 2.160.9 with conventional CCTA to 3.160.7 with subtraction CCTA (p,0.001). The segmentbased diagnostic accuracy for detecting significant stenosis according to ICA revealed an area under the receiver-operating characteristic curve of 0.722 for conventional CCTA and 0.892 for subtraction CCTA (p 5 0.036). Conclusion: Modified subtraction CCTA allows the breathholding time to be shortened to ,15 s. As compared with conventional CCTA, modified subtraction CCTA showed improvement in image quality and diagnostic accuracy in patients with limited breath-hold capability and severe calcification.
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U2 - 10.1259/bjr.20160489
DO - 10.1259/bjr.20160489
M3 - Article
C2 - 27439592
AN - SCOPUS:84989956171
SN - 0007-1285
VL - 89
JO - British Journal of Radiology
JF - British Journal of Radiology
IS - 1066
M1 - 20160489
ER -