Difference in self-assembling morphology of peptide nanorings

Hajime Okamoto, Tetsuo Yamada, Hiroshi Miyazaki, Tsutomu Nakanishi, Kyozaburo Takeda, Kenji Usui, Ikuo Obataya, Hisakazu Mhara, Hiroaki Azehara, Wataru Mizutani, Katsushi Hashimoto, Hiroshi Yamaguchi, Yoshiro Hirayama

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5 Citations (Scopus)


We synthesized the peptide nanorings of cyclo[-(D-Ala-L-Gln)3], cyclo[-(D-Cys-L-Gln)3], cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] and cyclo[-(L-Gln)3], and studied the way in which the difference in the type and/or number of component amino acid residues changes the self-assembling morphology of the nanorings on gold substrates by atomic force microscopy. The study revealed that cyclo[-(D-Ala-L-Gln)3] formed nanotube bundles through inter-ring hydrogen bonds, while the nanorings of cyclo[-(D-Cys-L-Gln)3] adhered to the gold surface directly due to the high affinity of thiol to gold. In contrast, a random amino acid sequence of cyclo[-D-Cys-L-His-D-Ala-L-Asn-Gly-L-Gln-] resulted in many isolated nanotubes, which were first observed in the present study. While the D,L-peptide nanotubes have very straight forms, the homo-L-peptide of cyclo[-(L-Gln)5] formed interesting randomly branching nanotubes that were entwined and grew on the substrate. Scanning tunneling microscopy was also performed and high-resolution images of both the peptide nanotubes and the nanotube bundles were obtained.

Original languageEnglish
Pages (from-to)8240-8248
Number of pages9
JournalJapanese Journal of Applied Physics
Issue number11
Publication statusPublished - 2005 Nov 9


  • Atomic force microscopy
  • Cyclic peptide
  • Nanotube
  • Scanning tunneling microscopy
  • Self-assembly, synthesis


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