TY - JOUR
T1 - Differences in oligosaccharide pattern of a sample of polar bear colostrum and mid-lactation milk
AU - Urashima, Tadasu
AU - Nagata, Hiromi
AU - Nakamura, Tadashi
AU - Arai, Ikichi
AU - Saito, Tadao
AU - Imazu, Koji
AU - Hayashi, Teruaki
AU - Derocher, Andrew E.
AU - Wiig, Oystein
N1 - Funding Information:
The Norwegian Polar Institute funded the capture of polar bears. All methods used in the capture and handling of polar bears were conducted in accordance with the principles and guidelines of the Norwegian Animal Welfare Act under permission from the Norwegian National Animal Research Authority. This study was partially supported by a Grant-in-Aid for Scientific Research (B) in Japan, grant number 13575026 and also by a grant from The 21th Century COE Program (A-1), Ministry of Education, Culture, Sports, Science, and Technology, Japan.
PY - 2003/12
Y1 - 2003/12
N2 - Although the concentrations of carbohydrate in the colostrum and in the mid-lactation milk of polar bear (Ursus maritimus) were similar, the oligosaccharide patterns differed. The colostrum sample contained Neu5Ac(α2-3)Gal(β1-4)Glc (3′-N-acetylneuraminyllactose), GalNAc(α1-3)[Fuc(α1-2)]Gal(β1-4)Glc (A-tetrasaccharide), Fuc(α1-2)Gal(β1-4)Glc (2′-fucosyllactose) and Gal(β1-4) Glc (lactose). The mid-lactation milk contained Gal(α1-3)[Fuc(α1-2)] Gal(β1-4)[Fuc(α1-3)]Glc (B-pentasaccharide), GalNAc(α1-3) [Fuc(α1-2)]Gal(β1-4)[Fuc(α1-3)]Glc (A-pentasaccharide), Gal(α1-3)[Fuc(α1-2)]Gal(β1-4)Glc (B-tetrasaccharide), A-tetrasaccharide, Gal(α1-3)Gal(β1-4)[Fuc(α1-3)]Glc (3-fucosylisoglobotriose), Gal(α1-3)Gal(β1-4)Glc (isoglobotriose) and lactose. The dominant saccharides in the colostrum were 3′-N- Acetylneuraminyllactose and lactose, whereas isoglobotriose was the dominant saccharide in the mid-lactation milk in which lactose was only a minor component. Isoglobotriose, which had previously been found to be a dominant saccharide in mature milk from the Ezo brown bear, the Japanese black bear and the polar bear, was not found in the polar bear colostrum.
AB - Although the concentrations of carbohydrate in the colostrum and in the mid-lactation milk of polar bear (Ursus maritimus) were similar, the oligosaccharide patterns differed. The colostrum sample contained Neu5Ac(α2-3)Gal(β1-4)Glc (3′-N-acetylneuraminyllactose), GalNAc(α1-3)[Fuc(α1-2)]Gal(β1-4)Glc (A-tetrasaccharide), Fuc(α1-2)Gal(β1-4)Glc (2′-fucosyllactose) and Gal(β1-4) Glc (lactose). The mid-lactation milk contained Gal(α1-3)[Fuc(α1-2)] Gal(β1-4)[Fuc(α1-3)]Glc (B-pentasaccharide), GalNAc(α1-3) [Fuc(α1-2)]Gal(β1-4)[Fuc(α1-3)]Glc (A-pentasaccharide), Gal(α1-3)[Fuc(α1-2)]Gal(β1-4)Glc (B-tetrasaccharide), A-tetrasaccharide, Gal(α1-3)Gal(β1-4)[Fuc(α1-3)]Glc (3-fucosylisoglobotriose), Gal(α1-3)Gal(β1-4)Glc (isoglobotriose) and lactose. The dominant saccharides in the colostrum were 3′-N- Acetylneuraminyllactose and lactose, whereas isoglobotriose was the dominant saccharide in the mid-lactation milk in which lactose was only a minor component. Isoglobotriose, which had previously been found to be a dominant saccharide in mature milk from the Ezo brown bear, the Japanese black bear and the polar bear, was not found in the polar bear colostrum.
KW - Colostrum
KW - Isoglobotriose
KW - Lactation
KW - Milk composition
KW - Milk oligosaccharides
KW - Polar bear
KW - Ursus maritimus
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U2 - 10.1016/j.cbpc.2003.09.001
DO - 10.1016/j.cbpc.2003.09.001
M3 - Article
C2 - 14662310
AN - SCOPUS:0344665754
SN - 1096-4959
VL - 136
SP - 887
EP - 896
JO - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
JF - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
IS - 4
ER -