TY - JOUR
T1 - Different cortical involvement pattern of generalized and localized spasms
T2 - A magnetoencephalography study
AU - Kakisaka, Yosuke
AU - Gupta, Ajay
AU - Wang, Zhong I.
AU - Dubarry, Anne Sophie
AU - Alexopoulos, Andreas V.
AU - Mosher, John C.
AU - Burgess, Richard C.
N1 - Funding Information:
This work was supported in part by Grants R01-EB009048 and R01-EB002010 from the National Institute of Biomedical Imaging and Bioengineering and Grant DP2 OD006469-01 from the National Institute of General Medical Sciences.
PY - 2011/11
Y1 - 2011/11
N2 - We report successful magnetoencephalography (MEG) recording in a child who had generalized epileptic spasms (ESs) as well as ESs involving the legs only during the recording. MEG source localization results demonstrated that (1) the interictal epileptiform discharges and both types of ESs had the same origin, that is, the right parietal region, and (2) the two types of ESs had different cortical spread patterns, that is, epileptic involvement localized to the right parietal region in spasms of the legs and rapid diffuse involvement in generalized spasms. In this case, MEG provided new insight into the mechanisms underlying the two types of ESs: both types were generated from the same focus, and in generalized ESs, abnormal excitation spread to cortical areas diffusely.
AB - We report successful magnetoencephalography (MEG) recording in a child who had generalized epileptic spasms (ESs) as well as ESs involving the legs only during the recording. MEG source localization results demonstrated that (1) the interictal epileptiform discharges and both types of ESs had the same origin, that is, the right parietal region, and (2) the two types of ESs had different cortical spread patterns, that is, epileptic involvement localized to the right parietal region in spasms of the legs and rapid diffuse involvement in generalized spasms. In this case, MEG provided new insight into the mechanisms underlying the two types of ESs: both types were generated from the same focus, and in generalized ESs, abnormal excitation spread to cortical areas diffusely.
KW - Dynamic statistical parametric mapping
KW - Epileptic spasms
KW - Magnetoencephalography
KW - Single dipole analysis
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U2 - 10.1016/j.yebeh.2011.08.011
DO - 10.1016/j.yebeh.2011.08.011
M3 - Article
C2 - 21944062
AN - SCOPUS:80054976282
SN - 1525-5050
VL - 22
SP - 599
EP - 601
JO - Epilepsy and Behavior
JF - Epilepsy and Behavior
IS - 3
ER -