Differential actin-regulatory activities of tropomodulin1 and tropomodulin3 with diverse tropomyosin and actin isoforms

Sawako Yamashiro; David S. Gokhin; Zhenhua Sui; Sarah E. Bergeron; Peter A. Rubenstein; Velia M. Fowler

doi:10.1074/jbc.M114.555128

Differential actin-regulatory activities of tropomodulin1 and tropomodulin3 with diverse tropomyosin and actin isoforms

Sawako Yamashiro, David S. Gokhin, Zhenhua Sui, Sarah E. Bergeron, Peter A. Rubenstein, Velia M. Fowler

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Background: Tropomodulins (Tmods) cap pointed ends of actin filaments in a tropomyosin (TM)-dependent manner.Results: Tmod1 and Tmod3 similarly cap actin filaments with diverseTMand actin isoforms, but only Tmod3 sequestersβ- andγ_cyto-actin monomers.Conclusion: Isoform-specific actin monomer sequestration by Tmod3 may provide a mechanism for actin remodeling inTM-deficient regions of cells.Significance: Defining the actin-regulatory activities of Tmods illuminates cytoskeletal dynamics.

Original language	English
Pages (from-to)	11616-11629
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	289
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M114.555128
Publication status	Published - 2014 Apr 25

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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abstract = "Background: Tropomodulins (Tmods) cap pointed ends of actin filaments in a tropomyosin (TM)-dependent manner.Results: Tmod1 and Tmod3 similarly cap actin filaments with diverseTMand actin isoforms, but only Tmod3 sequestersβ- andγcyto-actin monomers.Conclusion: Isoform-specific actin monomer sequestration by Tmod3 may provide a mechanism for actin remodeling inTM-deficient regions of cells.Significance: Defining the actin-regulatory activities of Tmods illuminates cytoskeletal dynamics.",

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AU - Yamashiro, Sawako

AU - Gokhin, David S.

AU - Sui, Zhenhua

AU - Bergeron, Sarah E.

AU - Rubenstein, Peter A.

AU - Fowler, Velia M.

PY - 2014/4/25

Y1 - 2014/4/25

N2 - Background: Tropomodulins (Tmods) cap pointed ends of actin filaments in a tropomyosin (TM)-dependent manner.Results: Tmod1 and Tmod3 similarly cap actin filaments with diverseTMand actin isoforms, but only Tmod3 sequestersβ- andγcyto-actin monomers.Conclusion: Isoform-specific actin monomer sequestration by Tmod3 may provide a mechanism for actin remodeling inTM-deficient regions of cells.Significance: Defining the actin-regulatory activities of Tmods illuminates cytoskeletal dynamics.

AB - Background: Tropomodulins (Tmods) cap pointed ends of actin filaments in a tropomyosin (TM)-dependent manner.Results: Tmod1 and Tmod3 similarly cap actin filaments with diverseTMand actin isoforms, but only Tmod3 sequestersβ- andγcyto-actin monomers.Conclusion: Isoform-specific actin monomer sequestration by Tmod3 may provide a mechanism for actin remodeling inTM-deficient regions of cells.Significance: Defining the actin-regulatory activities of Tmods illuminates cytoskeletal dynamics.

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Differential actin-regulatory activities of tropomodulin1 and tropomodulin3 with diverse tropomyosin and actin isoforms

Abstract

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