Differential expression of Tbx4 and Tbx5 in Zebrafish Fin buds

Koji Tamura, Sayuri Yonei-Tamura, Juan Carlos Izpisúa Belmonte

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalMechanisms of Development
Issue number1-2
Publication statusPublished - 1999 Sept 1


  • Embryogenesis
  • Fin bud
  • Gene expression
  • T-box
  • Tbx4
  • Tbx5
  • Zebrafish


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