TY - JOUR
T1 - Differential expression of Tbx4 and Tbx5 in Zebrafish Fin buds
AU - Tamura, Koji
AU - Yonei-Tamura, Sayuri
AU - Belmonte, Juan Carlos Izpisúa
N1 - Funding Information:
This work was supported by JSPS Postdoctoral Fellowships for Research Abroad to K.T. and by JSPS Research Fellowships for Young Scientists to S.Y.T. and by a grant from National Science Foundation to J.C.I.B. who is a Pew Scholar.
PY - 1999/9/1
Y1 - 1999/9/1
N2 - In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.
AB - In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. Copyright (C) 1999 Elsevier Science Ireland Ltd.
KW - Embryogenesis
KW - Fin bud
KW - Gene expression
KW - T-box
KW - Tbx4
KW - Tbx5
KW - Zebrafish
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U2 - 10.1016/S0925-4773(99)00126-4
DO - 10.1016/S0925-4773(99)00126-4
M3 - Article
C2 - 10495283
AN - SCOPUS:0032857541
SN - 0925-4773
VL - 87
SP - 181
EP - 184
JO - Mechanisms of Development
JF - Mechanisms of Development
IS - 1-2
ER -