Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with α,β-unsaturated aldehydes

Hiroaki Gotoh, Hayato Ishikawa, Yujiro Hayashi

Research output: Contribution to journalArticlepeer-review

217 Citations (Scopus)

Abstract

(Chemical Equation Presented) A catalytic enantioselective direct conjugate addition of nitroalkanes to α,β-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst has been developed. Using this methodology as a key step, short syntheses of therapeutically useful compounds have also been accomplished.

Original languageEnglish
Pages (from-to)5307-5309
Number of pages3
JournalOrganic Letters
Volume9
Issue number25
DOIs
Publication statusPublished - 2007 Dec 6

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