TY - JOUR
T1 - Direct association of adenosine deaminase with a T cell activation antigen, CD26
AU - Kameoka, Junichi
AU - Tanaka, Toshiaki
AU - Nojima, Yoshihisa
AU - Schlossman, Stuart F.
AU - Morimoto, Chikao
PY - 1993
Y1 - 1993
N2 - CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T cell lines, and an in vitro binding assay showed that the binding was through the extracellular domain of CD26. ADA deficiency causes severe combined immunodeficiency disease (SCID) in humans. Thus, ADA and CD26 (DPPIV) interact on the T cell surface, and this interaction may provide a clue to the pathophysiology of SCID caused by ADA deficiency.
AB - CD26, the T cell activation molecule dipeptidyl peptidase IV (DPPIV), associates with a 43-kilodalton protein. Amino acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA). ADA was coexpressed with CD26 on the Jurkat T cell lines, and an in vitro binding assay showed that the binding was through the extracellular domain of CD26. ADA deficiency causes severe combined immunodeficiency disease (SCID) in humans. Thus, ADA and CD26 (DPPIV) interact on the T cell surface, and this interaction may provide a clue to the pathophysiology of SCID caused by ADA deficiency.
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U2 - 10.1126/science.8101391
DO - 10.1126/science.8101391
M3 - Article
C2 - 8101391
AN - SCOPUS:0027201145
SN - 0036-8075
VL - 261
SP - 466
EP - 469
JO - Science
JF - Science
IS - 5120
ER -